178616-26-7
- CAS号:178616-26-7
- 英文名:1-(4'-AMINOPHENYL)-3,5-DIHYDRO-7,8-DIMETHOXY-4H-2,3-BENZODIAZEPIN-4-ONE
- 中文名:178616-26-7
- CBNumber:CB2280501
- 分子式:C17H17N3O3
- 分子量:311.34
- MOL File:178616-26-7.mol
- 密度 :1.32±0.1 g/cm3(Predicted)
- 储存条件 :Store at RT
- 溶解度 :Soluble in DMSO
- 酸度系数(pKa) :12.53±0.40(Predicted)
- 形态 :Off-white solid.
- 颜色 :Light yellow to khaki
178616-26-7性质、用途与生产工艺
- 生物活性 CFM-2 是一种有效的、选择性的、非竞争性的 AMPAR 拮抗剂。CFM-2 在不同的惊厥动物模型中均表现出抗惊厥活性。
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体外研究
CFM-2 inhibits the extracellular signal regulated kinase (ERK1/2) pathway, CFM-2 reduced phosphorylation of cAMP-responsive element binding protein (CREB), suppressed expression of cyclin D1, upregulated the cell cycle regulators and tumor suppressor proteins p21 and p53 and decreased number of lung adenocarcinoma cells in G2 and S phases of the cell cycle.
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体内研究
Pretreatment with CFM-2 delays the progression of seizure rank during repeated administration of pentylentetrazole. At the end of the period of repeated pentylentetrazole treatment (6 weeks) the mean seizure score was 0 in vehicle treated controls, 4.3 in animals treated with vehicle + pentylentetrazole, 2.2 in rats treated chronically with CFM-2 (20 μmol/kg; i.p.) + pentylentetrazole and 1.0 in rats treated repeatedly with CFM-2 (50 μmol/kg; i.p.) + pentylenetetrazole. CFM-2 is also able to antagonize the long-term increase in sensitivity of the convulsant effects of GABA function inhibitors in pentylentetrazole-kindled animals.Intrathecal application of two selective non-competitive AMPAR antagonists, CFM-2 (25 and 50 μg) and GYKI 52466 (50μg), significantly attenuated mechanical and thermal hypersensitivities on the ipsilateral hind paw at 2 and 24 h post-CFA injection. Neither CFM-2 nor GYKI 52466 affects the contralateral basal responses to thermal and mechanical stimuli.
- 更新日期:2024/11/08
- 产品编号:HY-12503
- 产品名称:CFM-2
- CAS编号:
- 包装:5 mg
- 价格:906元
- 更新日期:2024/11/08
- 产品编号:HY-12503
- 产品名称:178616-26-7 CFM-2
- CAS编号:178616-26-7
- 包装:10mg
- 价格:1450元
- 公司名称:EMMX Biotechnology LLC
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