ChemicalBook CAS数据库列表 WAY 161503盐酸盐
WAY 161503盐酸盐
- CAS号:75704-24-4
- 英文名:8,9-DICHLORO-2,3,4,4A-TETRAHYDRO-1H-PYRAZINO[1,2-A]QUINOXALIN-5(6H)-ONE HYDROCHLORIDE
- 中文名:WAY 161503盐酸盐
- CBNumber:CB2265207
- 分子式:C11H11Cl2N3O
- 分子量:272.13
- MOL File:75704-24-4.mol
WAY 161503盐酸盐化学性质
- 沸点 :513.9±50.0 °C(Predicted)
- 密度 :1.54±0.1 g/cm3(Predicted)
- 储存条件 :Desiccate at RT
- 溶解度 :DMF: 30 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 25 mg/ml; Ethanol: 1 mg/ml
- 形态 :A crystalline solid
- 酸度系数(pKa) :12.09±0.20(Predicted)
- 颜色 :Off-white to light yellow
WAY 161503盐酸盐性质、用途与生产工艺
-
用途
WAY 161503盐酸盐是一种有效的、选择性的、高亲和力的 5-HT2C 受体激动剂，具有抗肥胖和抗抑郁的作用。
-
靶点
5-HT 2C Receptor
4 nM (Ki)
5-HT 2C Receptor
12 nM (EC 50 )
-
体内研究
(Rac)-WAY-161503 (3-30 mg/kg; intraperitoneal injection; male C57BL/6J mice) treatment dose-dependently decreases locomotor activity, an effect that is blocked by the 5-HT 2C/2B antagonist SER-082. Additionally, the decreased locomotor activity produced by 10 mg/kg DOI is potentiated in the 5-HT 2A KO mice.
Animal Model: Male C57BL/6J mice with hallucinogen 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) Dosage: 3 mg/kg, 10 mg/kg, 30 mg/kg Administration: Intraperitoneal injection Result: Dose-dependently decreased locomotor activity, an effect that was blocked by the 5-HT 2C/2B antagonist SER-082.
WAY 161503盐酸盐上下游产品信息
上游原料
下游产品
WAY 161503盐酸盐生产厂家
- 公司名称：Service Chemical Inc.
- 联系电话：--
- 电子邮件：sales@chemos-group.com
- 国家：德国
- 产品数：6350
- 优势度：71
- 公司名称：BIOTREND Chemicals AG
- 联系电话：--
- 电子邮件：info@biotrend.ch
- 国家：德国
- 产品数：1250
- 优势度：62
75704-24-4, WAY 161503盐酸盐相关搜索:
