ChemicalBook CAS数据库列表 (2E,4E,6Z)-3-Methyl-7-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-3-propoxy-3-naphthalenyl)-2,4,6-octatrienoicacid

(2E,4E,6Z)-3-Methyl-7-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-3-propoxy-3-naphthalenyl)-2,4,6-octatrienoicacid

CAS号:180713-37-5
英文名:(2E,4E,6Z)-3-Methyl-7-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-3-propoxy-3-naphthalenyl)-2,4,6-octatrienoicacid
中文名:(2E,4E,6Z)-3-Methyl-7-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-3-propoxy-3-naphthalenyl)-2,4,6-octatrienoicacid
CBNumber:CB22518831
分子式:C26H36O3
分子量:396.56
MOL File:180713-37-5.mol

(2E,4E,6Z)-3-Methyl-7-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-3-propoxy-3-naphthalenyl)-2,4,6-octatrienoicacid化学性质

安全信息

(2E,4E,6Z)-3-Methyl-7-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-3-propoxy-3-naphthalenyl)-2,4,6-octatrienoicacid性质、用途与生产工艺

生物活性 LG100754 (UVI 2112) 是一种 RXR 二聚体的调节剂。LG100754 作为同源二聚体 RXR:RXR 的拮抗剂，但作为异源二聚体 RXR: PPARα 和 RXR: PPARγ 的激动剂。LG100754 是一种通过 RXR 起作用的胰岛素增敏剂。
靶点

PPARα

PPARγ
体外研究

LG100754 is a selective activator of endogenous RXR heterodimers.
LG100754 can also improve TNFα-mediated insulin resistance in mature adipocytes.
LG100754 acts as a bona fide activator of endogenous RXR:PPARγ heterodimers and regulator of insulin-dependent signaling pathways.
体内研究

LG100754 (100 mg/kg) completely blocks the increase in glucose levels, suggesting that LG100754 can improve insulin resistance in vivo.

(2E,4E,6Z)-3-Methyl-7-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-3-propoxy-3-naphthalenyl)-2,4,6-octatrienoicacid上下游产品信息

上游原料

下游产品

更新日期：2024/11/08
产品编号：HY-108523
产品名称：(2E,4E,6Z)-3-Methyl-7-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-3-propoxy-3-naphthalenyl)-2,4,6-octatrienoicacid LG100754
CAS编号：180713-37-5
包装：5mg
价格：3800元

(2E,4E,6Z)-3-Methyl-7-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-3-propoxy-3-naphthalenyl)-2,4,6-octatrienoicacid生产厂家