2-氯-N-[(1R)-1-(3-甲氧基苯基)乙基]苯丙胺盐酸盐

2-氯-N-[(1R)-1-(3-甲氧基苯基)乙基]苯丙胺盐酸盐化学性质

2-氯-N-[(1R)-1-(3-甲氧基苯基)乙基]苯丙胺盐酸盐性质、用途与生产工艺

生物活性 Tecalcet Hydrochloride (R 568 Hydrochloride) 是一个口服有效的拟钙剂，变构正调控钙敏感受体 (CaSR)。Tecalcet Hydrochloride (R 568 Hydrochloride) 可提高激活细胞外Ca2+的敏感性。
体外研究

Tecalcet (NPS 568, 0.1-100 μM) increase [Ca ²⁺ ]i in a concentrationdependent and stereoselective manner.
Tecalcet (NPS 568, 0.1-100 nM) shiftes the concentration-response curve for extracellular Ca ²⁺ to the left without affecting the maximal response and, thereby, decreases the EC ₅₀ value for extracellular Ca21 to 0.61±0.04 mM.

体内研究

Tecalcet (1.5 and 15 mg/kg, orally, twice daily for 4 days) inhibits PT cell proliferation in rats with renal insufficiency.

Animal Model:	10-wk-old Male Sprague-Dawley rats weighing 310-350 g.
Dosage:	1.5 and 15 mg/kg.
Administration:	Orally twice daily for 4 days.
Result:	Did not significantly change serum 1,25 (OH) ₂ D ₃ levels. In contrast, serum PTH levels were reduced by in a dose-dependent manner. Clearly reduced the number of BrdU-positive PT cells by 20% at a low dose (1.5 mg/kg body wt), and by 50% at a high dose (15 mg/kg body wt), indicating an antiproliferative effect on PT cells. Reduced PT cell volume in a dose-dependent manner.

2-氯-N-[(1R)-1-(3-甲氧基苯基)乙基]苯丙胺盐酸盐上下游产品信息

上游原料

下游产品

2-氯-N-[(1R)-1-(3-甲氧基苯基)乙基]苯丙胺盐酸盐生产厂家