TCN-201
- CAS号:852918-02-6
- 英文名:3-Chloro-4-fluoro-N-[4-[[2-(phenylcarbonyl)hydrazino]carbonyl]benzyl]benzenesulfonamide
- 中文名:TCN-201
- CBNumber:CB22518750
- 分子式:C21H17ClFN3O4S
- 分子量:461.89
- MOL File:852918-02-6.mol
- 储存条件 :2-8°C
- 溶解度 :DMSO: soluble5mg/mL (clear solution)
- 形态 :powder
- 颜色 :white to beige
- 危险品标志 :Xi
- 危险类别码 :22-36/37/38
- 安全说明 :26-36/37/39
- WGK Germany :3
TCN-201性质、用途与生产工艺
- 生物活性 TCN 201 是一种有效的，选择性和非竞争性的 GluN1/GluN2A NMDA 受体拮抗剂，pIC50 值为 6.8。与 GluN1/GluN2B NMDA 受体 (pIC50<4.3) 相比，TCN 201 对 GluN1/GluN2A NMDA 受体具有选择性。
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靶点
pIC50: 6.8 (GluN1/GluN2A NMDA receptor)
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体外研究
TCN 201 (compound 1) is selective for GluN1/GluN2A NMDAR over GluN1/GluN2B NMDAR, with pIC 50 s of 6.8 and <4.3, respectively.
TCN 201 (10 μM) produces only slight inhibition of GluN1/GluN2B NMDAR-mediated currents in oocytes.
TCN 201 (10-30 μM) antagonism of NMDAR-mediated responses is both subtype- and glycine-dependent and more potent than TCN 213 in oocytes.
TCN 201 (0.1-100 μM) does not produce complete block of NMDAR-mediated responses in oocytes.
TCN 201 (10 μM) antagonism of NMDAR-mediated currents shows a negative correlation with their ifenprodil sensitivity in rat cortical neurons.
TCN 201 (1-9 μM) suppresses cortical spreading depression (CSD) in chick retina. -
体内研究
TCN-201 (10 mg/kg; i.p.) is ineffective in CSD blood-oxygen level-dependent (BOLD) response in rats.
- 更新日期：2024/11/08
- 产品编号：HY-13457
- 产品名称：TCN 201
- CAS编号：
- 包装：1 mg
- 价格：242元
- 更新日期：2024/11/08
- 产品编号：HY-13457
- 产品名称：TCN 201
- CAS编号：
- 包装：5 mg
- 价格：605元
- 公司名称：Novachemistry
- 联系电话：44-20819178-90 02081917890
- 电子邮件：info@novachemistry.com
- 国家：英国
- 产品数：4381
- 优势度：58
- 公司名称：TOCRIS-US
- 联系电话：--
- 电子邮件：customerservice@tocris.co.uk
- 国家：英国
- 产品数：5726
- 优势度：77
