TCN-201

CAS号:852918-02-6
英文名:3-Chloro-4-fluoro-N-[4-[[2-(phenylcarbonyl)hydrazino]carbonyl]benzyl]benzenesulfonamide
中文名:TCN-201
CBNumber:CB22518750
分子式:C21H17ClFN3O4S
分子量:461.89
MOL File:852918-02-6.mol

TCN-201化学性质

安全信息

TCN-201性质、用途与生产工艺

生物活性 TCN 201 是一种有效的，选择性和非竞争性的 GluN1/GluN2A NMDA 受体拮抗剂，pIC50 值为 6.8。与 GluN1/GluN2B NMDA 受体 (pIC50<4.3) 相比，TCN 201 对 GluN1/GluN2A NMDA 受体具有选择性。
靶点

pIC50: 6.8 (GluN1/GluN2A NMDA receptor)
体外研究

TCN 201 (compound 1) is selective for GluN1/GluN2A NMDAR over GluN1/GluN2B NMDAR, with pIC ₅₀ s of 6.8 and <4.3, respectively.
TCN 201 (10 μM) produces only slight inhibition of GluN1/GluN2B NMDAR-mediated currents in oocytes.
TCN 201 (10-30 μM) antagonism of NMDAR-mediated responses is both subtype- and glycine-dependent and more potent than TCN 213 in oocytes.
TCN 201 (0.1-100 μM) does not produce complete block of NMDAR-mediated responses in oocytes.
TCN 201 (10 μM) antagonism of NMDAR-mediated currents shows a negative correlation with their ifenprodil sensitivity in rat cortical neurons.
TCN 201 (1-9 μM) suppresses cortical spreading depression (CSD) in chick retina.
体内研究

TCN-201 (10 mg/kg; i.p.) is ineffective in CSD blood-oxygen level-dependent (BOLD) response in rats.

TCN-201上下游产品信息

上游原料

下游产品

TCN-201 试剂级价格

TCN-201生产厂家

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