ChemicalBook CAS数据库列表 CHPG SODIUM SALT
CHPG SODIUM SALT
- CAS号:1303993-73-8
- 英文名:(RS)-2-Chloro-5-hydroxyphenylglycinesodiumsalt
- 中文名:CHPG SODIUM SALT
- CBNumber:CB22518684
- 分子式:C8H7ClNNaO3
- 分子量:225.6
- MOL File:1303993-73-8.mol
CHPG SODIUM SALT化学性质
- 储存条件 :Store at RT
- 溶解度 :Soluble to 50 mM in water and to 50 mM in DMSO
- 形态 :Powder
- 颜色 :Brown
CHPG SODIUM SALT性质、用途与生产工艺
- 生物活性 CHPG sodium salt 是一个选择性的 mGluR5 激动剂，并且通过 TSG-6/NF-κB 途径减弱 BV2 小神经胶质细胞 SO2 诱导的氧化应激和炎症。 CHPG sodium salt 通过 ERK 和 Akt 途径在体外和体内预防创伤性脑损伤 (TBI)。
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靶点
mGlu 5
NF-κB
ERK
Akt
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体外研究
CHPG sodium salt (10-500 µM; 24 hours) significantly increases the cell viability and decreases the LDH release after SO 2 derivatives treatment.
CHPG sodium salt (0.5 mM; 30 mins ) protects BV2 cells against SO 2 -induced apoptosis.
CHPG sodium salt (0.5 mM; 30 mins) treatment alone increases the expression of TSG-6 in both mRNA and protein levels.
Cell Viability Assay
Cell Line: BV2 microglial cells Concentration: 10, 50, 100 and 500 µM Incubation Time: 24 hours Result: Increased the cell viability. Apoptosis Analysis
Cell Line: BV2 microglial cells Concentration: 0.5 mM Incubation Time: 30 mins Result: Protected BV2 cells against SO 2 -induced apoptosis. Western Blot Analysis
Cell Line: BV2 microglial cells Concentration: 0.5 mM Incubation Time: 30 mins Result: Increased the expression of TSG-6 in both mRNA and protein levels. -
体内研究
CHPG sodium salt (injection; 250 nM; for 7 days) reduces significantly cerebral lesion volume.
Animal Model: Adult Sprague-Dawley male rats weighing 280-320 g Dosage: 250 nM Administration: Injection; for 7 days Result: Reduced significantly cerebral lesion volume.
CHPG SODIUM SALT上下游产品信息
上游原料
下游产品
CHPG SODIUM SALT 试剂级价格
- 更新日期：2024/11/08
- 产品编号：HY-101364A
- 产品名称：CHPG SODIUM SALT CHPG sodium salt
- CAS编号：1303993-73-8
- 包装：5mg
- 价格：500元
- 更新日期：2024/11/08
- 产品编号：HY-101364A
- 产品名称：CHPG SODIUM SALT CHPG sodium salt
- CAS编号：1303993-73-8
- 包装：10 mg
- 价格：800元
CHPG SODIUM SALT生产厂家
- 公司名称：TOCRIS-US
- 联系电话：--
- 电子邮件：customerservice@tocris.co.uk
- 国家：英国
- 产品数：5726
- 优势度：77
