6-甲氧基-3-吡啶羧胺
- CAS号:7150-23-4
- 英文名:6-Methoxynicotinamide
- 中文名:6-甲氧基-3-吡啶羧胺
- CBNumber:CB22463564
- 分子式:C7H8N2O2
- 分子量:152.15
- MOL File:7150-23-4.mol
- 熔点 :178-180°C
- 沸点 :301.6±22.0 °C(Predicted)
- 密度 :1.213±0.06 g/cm3(Predicted)
- 储存条件 :-20°C Freezer
- 溶解度 :DMSO (Slightly), Methanol (Slightly)
- 形态 :Solid
- 酸度系数(pKa) :15.17±0.50(Predicted)
- 颜色 :Off-White to Pale Beige
- InChI :InChI=1S/C7H8N2O2/c1-11-6-3-2-5(4-9-6)7(8)10/h2-4H,1H3,(H2,8,10)
- InChIKey :KXDSMFBEVSJYRF-UHFFFAOYSA-N
- SMILES :C1=NC(OC)=CC=C1C(N)=O
- 海关编码 :2933399990
6-甲氧基-3-吡啶羧胺性质、用途与生产工艺
- 生物活性 JBSNF-000088 (6-Methoxynicotinamide)是一种 烟酰胺（NA）的类似物，是 Nicotinamide N-methyltransferase (NNMT) 的有效抑制剂，对 human NNMT(hNNMT)、monkey NNMT (mkNNMT) 和 mouse NNMT (mNNMT)的IC50值为1.8 µM、2.8 µM 和 5.0 µM。
-
靶点
Target Value hNNMT
(Cell-free assay)1.8 μM mkNNM
(Cell-free assay)2.8 μM mNNMT
(Cell-free assay)5.0 μM -
体外研究
JBSNF-000088 (6-Methoxynicotinamide) has IC 50 values are 1.6 and 6.3 µM for U2OS or differentiated 3T3L1 cells.
-
体内研究
JBSNF-000088 (6-Methoxynicotinamide) (50 mg/kg; oral route of administration for four weeks) shows statistically significant reduction in body weight (%) and leads to a statistically significant reduction in fed blood glucose on day 21.
JBSNF-000088 (50 mg/kg; oral gavage administration; twice daily for four weeks) leads to a statistically significant improvement in oral glucose tolerance on day 28 with glucose tolerance being normalized.
JBSNF-000088 (1 mg/kg; intravenous administration; for 4 hours) results in low plasma clearance of 21 mL/min▪kg and the volume of distribution at steady state of 0.7 L/kg, a very short plasma half-life of 0.5 hours upon intravenous administration.
JBSNF-000088 (10 mg/kg; oral gavage; for 4 hours) results in a Cmax of 3568 ng/mL with a T max value of 0.5 hours, indicating rapid absorption in the intestine, and half-life of 0.4 hours by oral gavage. The oral bioavailability is found to be approximately 40%.
Animal Model: Mice with high fat diet (HFD)-induced obesity Dosage: 50 mg/kg Administration: Oral route of administration for four weeks; oral gavage administration and twice daily for four weeks Result: Showed statistically significant reduction in body weight (%) and led to a statistically significant reduction in fed blood glucose on day 21 by oral route of administration.
Led to a statistically significant improvement in oral glucose tolerance on day 28 with glucose tolerance being normalized by oral gavage administration.Animal Model: C57BL/6 mice Dosage: 1 mg/kg (Intravenous administration);10 mg/kg (oral gavage)(Pharmacokinetic Study) Administration: Intravenous administration and oral gavage; for 4 hours Result: Resulted in low plasma clearance of 21 mL/min▪kg and the volume of distribution at steady state of 0.7 L/kg, a very short plasma half-life of 0.5 h upon intravenous administration.
Resulted in a Cmax of 3568 ng/mL with a T max value of 0.5 hours, indicating rapid absorption in the intestine, and half-life of 0.4 hours by oral gavage.
- 更新日期：2024/11/08
- 产品编号：XW02715023403
- 产品名称：6-甲氧基-3-吡啶羧胺
- CAS编号：7150-23-4
- 包装：1G
- 价格：409元
- 更新日期：2024/11/08
- 产品编号：S6779
- 产品名称：6-甲氧基-3-吡啶羧胺 JBSNF-000088
- CAS编号：7150-23-4
- 包装：25mg
- 价格：470.74元
- 公司名称：A.J Chemicals
- 联系电话：--
- 电子邮件：sales@ajchem.in
- 国家：印度
- 产品数：6100
- 优势度：58
- 公司名称：CHEMSWORTH
- 联系电话：--
- 电子邮件：info@chemsworth.com
- 国家：印度
- 产品数：6700
- 优势度：30
