SULFOSUCCINIMIDYL OLEATE
- CAS号:135661-44-8
- 英文名:Sulfosuccinimidyl Oleate Sodium
- 中文名:SULFOSUCCINIMIDYL OLEATE
- CBNumber:CB21564909
- 分子式:C22H37NO7S
- 分子量:459.6
- MOL File:135661-44-8.mol
- 熔点 :220-2220C
- 密度 :1.19±0.1 g/cm3(Predicted)
- 储存条件 :-20°C Freezer
- 溶解度 :DMSO (Slightly), Methanol (Slightly, Heated)
- 形态 :Solid
- 酸度系数(pKa) :-0.04±0.20(Predicted)
- 颜色 :White to Off-White
- 稳定性 :Hygroscopic
- 海关编码 :2928009090
SULFOSUCCINIMIDYL OLEATE性质、用途与生产工艺
- 生物活性 Sulfosuccinimidyl oleate (Sulfo-N-succinimidyl oleate) 是一种长链脂肪酸，抑制脂肪酸向细胞转运。Sulfosuccinimidyl oleate 是一种有效且不可逆的线粒体呼吸链抑制剂。Sulfosuccinimidyl oleate 结合小胶质细胞表面上的 CD36 受体。具有抗炎作用。
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体外研究
Sulfosuccinimidyl oleate (20 μM and 50 μM, 24 hours) alone does not alter the cellular viability. Exposure to 100 ng/ml LPS+5 ng/mL IFNγ modestly, yet significantly reduces the viability of the BV2 cells. Co-treatment with Sulfosuccinimidyl oleate prevents the LPS+IFNγ-induced reduction in the cell viability.
Sulfosuccinimidyl oleate (50 μM, 24 hours) co-treatment significantly reduces the LPS+IFNγ-induced expression of NOS2 and COX-2 in BV2 cells. Western blot analysis reveals a significant LPS/IFNγ-induced upregulation in the phosphorylated form of the p38, which is prevented by co-treatment with Sulfosuccinimidyl oleate (50 μM, 24 hours).
Cell Viability Assay
Cell Line: BV2 cells Concentration: 20 μM and 50 μM Incubation Time: 24 hours Result: Did not alter the viability of BV2 cells alone. Exposure of BV2 cells to 100 ng/mL LPS and 5 ng/mL IFNγ significantly reduced the viability of BV2 cells while simultaneous treatment with Sulfosuccinimidyl oleate prevented it. Western Blot Analysis
Cell Line: BV2 cells Concentration: 50 μM Incubation Time: 24 hours Result: Drastically increased the levels of NOS2, COX-2, and P-p38/T-p38. -
体内研究
Sulfosuccinimidyl oleate (50 mg/kg; administered once by single oral gavage) significantly reduces the cortical ischemic infarct size compared to vehicle-treated controls in male BALB/cABom mice with pMCAo model. In addition, Sulfosuccinimidyl oleate at 50 mg/kg is suitable to see a beneficial effect after stroke.
Animal Model: 4-month-old male BALB/cABom mice with pMCAo model Dosage: 50 mg/kg Administration: Administered once by single oral gavage Result: Reduced brain damage following ischemia. Attenuated infarct size.
- 更新日期：2024/08/19
- 产品编号：HY-112847A
- 产品名称：SULFOSUCCINIMIDYL OLEATE Sulfosuccinimidyl oleate sodium
- CAS编号：135661-44-8
- 包装：5mg
- 价格：800元
- 更新日期：2024/08/19
- 产品编号：HY-112847A
- 产品名称：SULFOSUCCINIMIDYL OLEATE Sulfosuccinimidyl oleate sodium
- CAS编号：135661-44-8
- 包装：10mM * 1mLin DMSO
- 价格：880元
- 公司名称：APOLLO-NMR
- 联系电话：--
- 电子邮件：sales@apolloscientific.co.uk
- 国家：英国
- 产品数：6097
- 优势度：88
