ChemicalBook CAS数据库列表 8-(1,3,4-OXADIAZOL-2-YL)-2,4-BIS(TRIFLUOROMETHYL)IMIDAZO[1,2-A][1,8]NAPHTHYRIDINE

8-(1,3,4-OXADIAZOL-2-YL)-2,4-BIS(TRIFLUOROMETHYL)IMIDAZO[1,2-A][1,8]NAPHTHYRIDINE

CAS号:691868-88-9
英文名:8-(1,3,4-OXADIAZOL-2-YL)-2,4-BIS(TRIFLUOROMETHYL)IMIDAZO[1,2-A][1,8]NAPHTHYRIDINE
中文名:8-(1,3,4-OXADIAZOL-2-YL)-2,4-BIS(TRIFLUOROMETHYL)IMIDAZO[1,2-A][1,8]NAPHTHYRIDINE
CBNumber:CB2134747
分子式:C14H5F6N5O
分子量:373.21
MOL File:Mol file

8-(1,3,4-OXADIAZOL-2-YL)-2,4-BIS(TRIFLUOROMETHYL)IMIDAZO[1,2-A][1,8]NAPHTHYRIDINE化学性质

8-(1,3,4-OXADIAZOL-2-YL)-2,4-BIS(TRIFLUOROMETHYL)IMIDAZO[1,2-A][1,8]NAPHTHYRIDINE性质、用途与生产工艺

生物活性 RO8191 (CDM-3008) 是一种咪唑啉并吡啶化合物，是具有口服活性的，有效的干扰素 (IFN) 受体激动剂。RO8191 直接与 IFNα/β 受体 2 (IFNAR2) 结合，激活 IFN 刺激的基因 (ISGs) 表达和 JAK/STAT 磷酸化。RO8191 对 HCV 和 EMCV 均显示抗病毒活性，对 HCV 复制子的 IC50 为 200 nM。RO8191 通过具有干扰素样活性发挥 cccDNA 调节剂 (CDM) 作用，并具有抗 HBV 活性。
靶点

JAK1

IFNAR2
体外研究

RO8191 (CDM-3008) exerts antiviral activity dependent on IFNAR2/JAK1, but is independent of IFNAR1/Tyk2. RO8191, an IFNAR2 agonist, stimulates IFN signals in mice.
RO8191 (0.08, 0.4, 2, 10 μM; for 72 h) strongly suppresses HCV replicon activity at 72 h in a dose-dependent manner. RO8191 reduces levels of the proteins HCV NS3 and NS4A, which are localized mainly in the perinuclear region of the replicon cells.
RO8191 (0.08-10 μM; for 72 h) results in the disappearance of viral proteins such as NS3, NS4A/B, and NS5A/B.
体内研究

RO8191 (CDM-3008; 30 mg/kg; oral) significantly induces antiviral genes Oas1b, Mx1, and Pkr in the livers of six-week-old C57BL/6J mice.

8-(1,3,4-OXADIAZOL-2-YL)-2,4-BIS(TRIFLUOROMETHYL)IMIDAZO[1,2-A][1,8]NAPHTHYRIDINE上下游产品信息

上游原料

下游产品

更新日期：2024/11/08
产品编号：HY-W063968
产品名称：8-(1,3,4-OXADIAZOL-2-YL)-2,4-BIS(TRIFLUOROMETHYL)IMIDAZO[1,2-A][1,8]NAPHTHYRIDINE RO8191
CAS编号：691868-88-9
包装：5mg
价格：1100元

8-(1,3,4-OXADIAZOL-2-YL)-2,4-BIS(TRIFLUOROMETHYL)IMIDAZO[1,2-A][1,8]NAPHTHYRIDINE生产厂家