Lactimidomycin
- CAS号:134869-15-1
- 英文名:Lactimidomycin
- 中文名:Lactimidomycin
- CBNumber:CB21120392
- 分子式:C26H35NO6
- 分子量:457.56
- MOL File:134869-15-1.mol
- 储存条件 :Store at -20°C
Lactimidomycin性质、用途与生产工艺
- 生物活性 Lactimidomycin 是从链霉菌中分离出的含戊二酰亚胺的化合物。Lactimidomycin 是一种有效的真核翻译延伸抑制剂，对肿瘤细胞系具有有效的抗增殖作用，并选择性抑制蛋白质翻译。Lactimidomycin 抑制蛋白质合成，IC50 值为 37.82 nM。Lactimidomycin 还是登革热病毒 2 和其他 RNA 病毒的有效且无毒的抑制剂。抗癌和抗病毒活性。
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靶点
Eukaryotic translation elongation
Dengue virus 2 and other RNA viruses -
体外研究
Lactimidomycin (0.01-100 nM; 24 hours; Hs 579T, HCC 1937, HCC 1395, HCC 2218, BT 474, MCF 7, MDA MB231 cells and MCF 10A) treatment inhibits cell growth with IC 50 concentrations in the low nanomolar range, but higher doses are necessary to inhibit growth of the non-tumorigenic breast cell line MCF10A.
Lactimidomycin induces a clear dose-responsive inhibition of DENV2 infectious particle production with an EC 90 value of 0.4 μM. No measurable decrease in cell viability was detected at concentrations up to 12.5 µM.
Lactimidomycin is a potent inhibitor of DENV2 and Lactimidomycin's inhibition of DENV2 translation leads to reduced production of newly infectious particles. Lactimidomycin may protect cells from viral cytopathic effects including apoptosis, likely through inhibition of virus protein production and replication.Cell Proliferation Assay
Cell Line: Hs 579T, HCC 1937, HCC 1395, HCC 2218, BT 474, MCF 7, MDA MB231 cells and MCF 10A Concentration: 0.01-100 nM Incubation Time: 24 hours Result: Inhibited cell growth with IC 50 concentrations in the low nanomolar range. -
体内研究
Lactimidomycin (0.6 mg/kg; intraperitoneal injection; daily; for one month; female nude mice) treatment has an appreciable effect on tumor growth in nude mice.
Animal Model: Female nude mice (6-8 week old) with MDA MB 231 cells Dosage: 0.6 mg/kg Administration: Intraperitoneal injection; daily; for one month Result: Had an appreciable effect on tumor growth in vivo.
- 更新日期：2024/01/25
- 产品编号：HY-18979
- 产品名称：Lactimidomycin Lactimidomycin
- CAS编号：134869-15-1
- 包装：200μg
- 价格：9700元
- 公司名称：北京普西唐生物科技有限公司
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- 国家：中国
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- 公司名称：TargetMol Chemicals Inc.
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- 国家：美国
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- 公司名称：天津普西唐生物医药科技有限公司
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- 公司名称：上海陌孚医药科技有限公司
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- 公司名称：GIHI CHEMICALS CO.,LIMITED
- 联系电话： +8618058761490
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- 国家：中国
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