3-amino-3-deoxy-D-glucose hydrochloride
- CAS号:57649-10-2
- 英文名:3-amino-3-deoxy-D-glucose hydrochloride
- 中文名:3-amino-3-deoxy-D-glucose hydrochloride
- CBNumber:CB1927513
- 分子式:C6H13NO5.ClH
- 分子量:0
- MOL File:57649-10-2.mol
- 储存条件 :Store at -20°C
- 溶解度 :≤5mg/ml in ethanol;25mg/ml in DMSO;25mg/ml in dimethyl formamide
- 形态 :crystalline solid
- 颜色 :White to off-white
- 稳定性 :Very Hygroscopic
3-amino-3-deoxy-D-glucose hydrochloride性质、用途与生产工艺
- 生物活性 Kanosamine hydrochloride是一种抗生素,可抑制植物病原卵菌,某些真菌 (fungi) 和细菌 (bacterial) 的生长。Kanosamine抑制 Phytophthora medicaginis M2913 和 Aphanomyces euteiches WI-98的MIC 分别为25 和 60 µg/mL。
-
靶点
MIC: 25 µg/mL ( Phytophthora medicaginis M2913), 60 µg/mL ( Aphanomyces euteiches WI-98)
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体外研究
Kanosamine is highly inhibitory to growth of plant-pathogenic oomycetes. Among the strains tested, Phytophthora medicaginis M2913 is the most sensitive to kanosamine, whereas Pythium aphanidermatum Pa138 and Pythium torulosum A25a are less sensitive, and Aphanomyces euteiches WI-98 shows an intermediate level of sensitivity. The oomycetes are more sensitive to kanosamine at pH 7.0 than at pH 5.6. Kanosamine inhibits few bacterial species. Kanosamine is moderately inhibitory to certain fungi. All of the fungi and oomycetes inhibited by kanosamine are pathogens of plants. Maximum accumulation of kanosamine in B. cereus UW85 culture supernatants coincided with sporulation. Kanosamine accumulation is enhanced by the addition of ferric iron and suppressed by addition of phosphate to rich medium. Kanosamine accumulation is also enhanced more than 300% by the addition of alfalfa seedling exudate to minimal medium. The antibiotic kanosamine inhibits growth of Saccharomyces cerevisiae and a range of human pathogenic fungi, including Candida albicans . The action of kanosamine on C. albicans cells results in profound morphological changes, inhibition of septum formation and cell agglutination.
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