地塞米松EP杂质E
- CAS号:13209-41-1
- 英文名:Dexamethasone EP Impurity E
- 中文名:地塞米松EP杂质E
- CBNumber:CB1921384
- 分子式:C22H28O4
- 分子量:356.46
- MOL File:13209-41-1.mol
- 熔点 :228-231 °C(Solv: acetone (67-64-1); hexane (110-54-3))
- 沸点 :548.3±50.0 °C(Predicted)
- 密度 :1.24±0.1 g/cm3(Predicted)
- 储存条件 :Refrigerator
- 溶解度 :Chloroform (Slightly), Dioxane (Slightly), Ethyl Acetate (Slightly)
- 形态 :Solid
- 酸度系数(pKa) :12.53±0.70(Predicted)
- 颜色 :Pale Yellow
地塞米松EP杂质E性质、用途与生产工艺
- 生物活性 Vamorolone (VBP15) 是首创的，具有口服活性的解离性类固醇 (dissociative steroidal) 抗炎药和膜稳定剂。Vamorolone 改善肌营养不良，无副作用。Vamorolone 抑制 (NF-κB) 抑制作用，并降低了激素的影响。
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体外研究
Vamorolone (VBP15) inhibits TNFα-induced pro-inflammatory NF-κB signaling in C2C12 muscle cells at 1 nM or more. Vamorolone binds the glucocorticoid receptor (GR) and mineralocorticoid receptor (MR) with similar affinity.
Vamorolone (0.1, 1μM; 30 minutes) reduces production of IL1βand CCL5 inflammatory mediators in primary human macrophages.
Vamorolone is a first-in-class mineralocorticoid receptor (MR) antagonist/dissociative glucocorticoid receptor (GR) ligand. -
体内研究
Vamorolone (5-30 mg/kg; cherry syrup) shows a superior side effect profile compared to pharmacological glucocorticoids in mdx mice.
Vamorolone (30 mg/kg; orally; daily for 20 days) reduces CNS Inflammation in murine experimental autoimmune encephalomyelitis.Animal Model: C57BL/6 mice (experimental autoimmune encephalomyelitis) Dosage: 30 mg/kg Administration: Orally; daily for 20 days (starting one day prior to MOG 33-55 peptide immunization and continuing) Result: Reduced CNS inflammation in murine experimental autoimmune encephalomyelitis.
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