ChemicalBook CAS数据库列表 Trastuzumab Deruxtecan
Trastuzumab Deruxtecan
- CAS号:1826843-81-5
- 英文名:Trastuzumab Deruxtecan
- 中文名:Trastuzumab Deruxtecan
- CBNumber:CB18081028
- 分子式:
- 分子量:0
- MOL File:Mol file
Trastuzumab Deruxtecan化学性质
- 储存条件 :Solution, -20°C, 2 years
- 溶解度 :Soluble in acetonitrile
- 形态 :Solid
- 颜色 :White to off-white
Trastuzumab Deruxtecan性质、用途与生产工艺
- 生物活性 Trastuzumab deruxtecan (DS-8201a) 是一种抗人表皮生长因子受体 2 (HER2) 抗体-药物偶联物 (ADC)。 Trastuzumab deruxtecan 由人源化抗 HER2 抗体，酶促裂解的肽接头和拓扑异构酶 I 抑制剂组成。Trastuzumab deruxtecan 可用于 HER2 阳性乳腺癌和胃癌的研究。
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体外研究
Trastuzumab deruxtecan (1 pM-10 nM; 5 days) inhibits the growth of HER2‐positive KPL‐4 cells, with an IC 50 of 109.7 pM.
Trastuzumab deruxtecan (10 nM; 5 days) shows bystander killing effects in HER2‐negative MDA‐MB‐468 cells.Cell Viability Assay
Cell Line: KPL‐4 and MDA‐MB‐468 cells Concentration: 1, 10, 100, 1000, 10000 pM Incubation Time: 5 days Result: Killed both HER2‐positive KPL‐4 cells and HER2‐negative MDA‐MB‐468 cells. -
体内研究
Trastuzumab deruxtecan (3 mg/kg; a single i.v.) shows antitumor activity against not only HER2‐positive tumors but also HER2‐negative tumors under the co‐inoculated condition.
Trastuzumab deruxtecan (10 mg/kg; i.v. on days 0 and 7) inhibits the tumor growth in in EMT6-hHER2 syngeneic mouse model.Animal Model: Female BALB/c nude mice injected with NCI‐N87 and MDA‐MB‐468‐Luc cells Dosage: 3 mg/kg Administration: A single i.v. Result: Almost all of the HER2‐positive and HER‐negative cells disappeared and there were little or no cancer cells remaining in the tumors.
Trastuzumab Deruxtecan上下游产品信息
上游原料
下游产品
Trastuzumab Deruxtecan 试剂级价格
- 更新日期：2024/08/19
- 产品编号：HY-138298A
- 产品名称：Trastuzumab Deruxtecan Trastuzumab deruxtecan
- CAS编号：1826843-81-5
- 包装：1 mg
- 价格：6400元
- 更新日期：2024/08/19
- 产品编号：HY-138298
- 产品名称：Trastuzumab Deruxtecan Trastuzumab deruxtecan
- CAS编号：1826843-81-5
- 包装：1mg(10mg/mL * 100μL in Aqueous solution)
- 价格：6400元
Trastuzumab Deruxtecan生产厂家
- 公司名称：MedChemExpress
- 联系电话：--
- 电子邮件：sales@medchemexpress.com
- 国家：美国
- 产品数：6398
- 优势度：58
