ChemicalBook CAS数据库列表 香橙素
香橙素
- CAS号:480-20-6
- 英文名:DIHYDROKAEMPFEROL
- 中文名:香橙素
- CBNumber:CB1772858
- 分子式:C15H12O6
- 分子量:288.25
- MOL File:480-20-6.mol
香橙素化学性质
- 熔点 :237～241℃
- 沸点 :139-140 °C
- 密度 :1.599±0.06 g/cm3(Predicted)
- 储存条件 :Sealed in dry,2-8°C
- 溶解度 :DMSO:2.88(Max Conc. mg/mL);10.0(Max Conc. mM)
- 形态 :Solid
- 酸度系数(pKa) :7.42±0.60(Predicted)
- 颜色 :White to off-white
- InChIKey :PADQINQHPQKXNL-LSDHHAIUSA-N
- LogP :2.860 (est)
- EPA化学物质信息 :4H-1-Benzopyran-4-one, 2,3-dihydro-3,5,7-trihydroxy-2-(4-hydroxyphenyl)-, (2R,3R)- (480-20-6)
安全信息
香橙素性质、用途与生产工艺
- 生物活性 Dihydrokaempferol 是从紫荆花 Bauhinia championii (Benth) 中分离得到的。 Dihydrokaempferol 诱导 apoptosis 并抑制 Bcl-2 和 Bcl-xL 的表达。Dihydrokaempferol 可以作为抗关节炎新药的良好候选。
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靶点
Apoptosis; Bcl-2; Bcl-xL
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体外研究
Dihydrokaempferol (0.3-300 μM; 48 hours) has no significant effect on normal synoviocytes, but dependently decreases the viability of RA-FLSs. Dihydrokaempferol (3-30 μM; 48 hours) increases the percentage of apoptotic cells (including early and late apoptotic cells; ~3.8% and ~9.6%, respectively). Dihydrokaempferol (3-30 μM; 48 hours) promotes Bax and Bad expression and inhibits Bcl-2 and Bcl-xL expression, increases the cleaved fragments of caspase-3, caspase-9 and cleaved PARP.
Cell Proliferation Assay
Cell Line: Normal synoviocyte cells; RA-FLS cells Concentration: 0.3 μM, 3 μM, 30 μM, 300 μM Incubation Time: 48 hours Result: Decreased the proliferation of RA-FLSs. Apoptosis Analysis
Cell Line: RA-FLS cells Concentration: 3 μM, 30 μM Incubation Time: 48 hours Result: Induced apoptosis in RA-FLSs. Western Blot Analysis
Cell Line: RA-FLS cells Concentration: 3 μM, 30 μM Incubation Time: 48 hours Result: Promoted Bax and Bad expression, increased the cleaved fragments of caspase-3, caspase-9 and cleaved PARP and inhibited Bcl-2 and Bcl-xL expression.
香橙素上下游产品信息
上游原料
下游产品
香橙素 试剂级价格
- 更新日期：2024/11/11
- 产品编号：XW48020601
- 产品名称：香橙素 Aromadendrin
- CAS编号：
- 包装：5mg
- 价格：3168元
- 更新日期：2024/11/08
- 产品编号：HY-N2897
- 产品名称：Dihydrokaempferol
- CAS编号：
- 包装：1 mg
- 价格：450元
香橙素生产厂家
- 公司名称：Chemodex Ltd.
- 联系电话：--
- 电子邮件：info@chemodex.com
- 国家：瑞士
- 产品数：1549
- 优势度：50
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