氧托溴铵
- CAS号:30286-75-0
- 英文名:OXITROPIUM BROMIDE
- 中文名:氧托溴铵
- CBNumber:CB1727939
- 分子式:C19H26BrNO4
- 分子量:412.32
- MOL File:30286-75-0.mol
- 熔点 :203-204° (dec)
- 比旋光度 :D21 -25° (c = 2.0 in water)
- 储存条件 :Hygroscopic, -20°C Freezer, Under inert atmosphere
- 溶解度 :Very soluble in water, freely soluble in methanol, sparingly soluble in ethanol (96 per cent), practically insoluble in methylene chloride.
- 颜色 :Off-White to Pale Yellow
- 稳定性 :Hygroscopic
- 毒性 :LD50 orl-rat: 2250 mg/kg DRFUD44,117,79
氧托溴铵性质、用途与生产工艺
- 生物活性 Oxitropium bromide 是毒蕈碱受体拮抗剂。Oxitropium bromide 具有抗胆碱能支气管扩张作用，能用于哮喘和慢性阻塞性肺疾病的研究。
-
靶点
mAChR
-
体外研究
Oxitropium bromide is a muscarinic antagonist which blocks musucarinic acetylcholine receptors (mAChR). Incubation with oxitropium bromide of untreated diaphragm muscle and diaphragm muscle injected with endotoxin does not increase the force-frequency curves dose-dependently in vitro ; however, it causes both types of muscle to be fatigue resistant.
-
体内研究
Oxitropium bromide inhalation shifts force-frequency curves upward at 2 h after inhalation and inhibits the decrease of force-frequency curves due to endotoxin injection in vivo . Oxitropium bromide strongly and persistently inhibits the acetylcholine (ACh)-induced resistance. The increase in resistance induced by histamine, serotonin, leukotriene D4 or antigen is prevented by oxitropium bromide oxitropium bromide. Inhalation of the anticholinergic agent oxitropium bromide at doses of 1.5 μg and higher greatly attenuates the decrease in mucus score produced by intravenous histamine but not by inhaled histamine.
- 公司名称：EDQM
- 联系电话：--
- 电子邮件：orders@edqm.eu
- 国家：法国
- 产品数：1913
- 优势度：81
