ChemicalBook CAS数据库列表 STAT3-IN-1
STAT3-IN-1
- CAS号:2059952-75-7
- 英文名:STAT3-IN-1
- 中文名:STAT3-IN-1
- CBNumber:CB15821188
- 分子式:C28H29NO6
- 分子量:475.53
- MOL File:2059952-75-7.mol
STAT3-IN-1化学性质
- 沸点 :689.3±55.0 °C(Predicted)
- 密度 :1.205±0.06 g/cm3(Predicted)
- 储存条件 :Sealed in dry,Room Temperature
- 溶解度 :DMSO: 125 mg/mL (262.86 mM)
- 酸度系数(pKa) :12.63±0.70(Predicted)
- 形态 :Solid
- 颜色 :Light yellow to orange
STAT3-IN-1性质、用途与生产工艺
- 生物活性 STAT3-IN-1 (compound 7d) 是一种出色的、选择性的 STAT3 的口服活性抑制剂，在HT29细胞和MDA-MB 231细胞中的IC50值分别为1.82 μM和2.14 μM。STAT3-IN-1 诱导肿瘤细胞凋亡。
-
靶点
Target Value STAT3
(in HT29 cells)1.82 μM STAT3
(in MDA-MB 231 cells)2.14 μM -
体外研究
STAT3-IN-1 (compound 7d: 0-10 μM, 48 h) inhibits the STAT3 acetylation at lysine 685 and affected its specific genes expressions.
STAT3-IN-1 (compound 7d: 0-10 μM, 48 h) induces tumor cells apoptosis in MDA-MB-231 cells.Apoptosis Analysis
Cell Line: MDA-MB-231 cell lines. Concentration: 0-10 μM. Incubation Time: 48 hours. Result: The induced apoptosis rates (early and late apoptosis) at 1, 2, 5, 8 and 10 μM were 9.0%, 11.2%, 20.9%, 43.3% and 85.2% versus control 3.0%. Western Blot Analysis
Cell Line: MDA-MB-231 and HT-29 cell lines. Concentration: 0-10 μM. Incubation Time: 48 hours. Result: Inhibited STAT3 acetylation and STAT3 tyrosine phosphorylation in MDA-MB-231 cells.
Increased the expressions of these tumor-suppressor genes (PTPN6 (SHP-1), CDKN2A and DLEC1) which were related to STAT3 acetylation at Lys685. -
体内研究
STAT3-IN-1 (compound 7d: 10, 20 mg/kg, two weeks) arrests tumor growth with low toxicity in mouse-xenograft model.
Animal Model: Mouse-xenograft model bearing inoculation of mice breast cancer 4T1 cells. Dosage: 10, 20 mg/kg. Administration: Oral administration once every other day for two weeks. Result: Arrested tumor growth with no obvious body weight loss.
STAT3-IN-1上下游产品信息
上游原料
下游产品
STAT3-IN-1 试剂级价格
- 更新日期：2024/11/08
- 产品编号：HY-100753
- 产品名称：STAT3-IN-1
- CAS编号：
- 包装：1 mg
- 价格：681元
- 更新日期：2024/11/08
- 产品编号：HY-100753
- 产品名称：STAT3-IN-1 STAT3-IN-1
- CAS编号：2059952-75-7
- 包装：5mg
- 价格：1500元
STAT3-IN-1生产厂家
- 公司名称：TargetMol Chemicals Inc.
- 联系电话：+1-781-999-5354 +1-00000000000
- 电子邮件：marketing@targetmol.com
- 国家：美国
- 产品数：32161
- 优势度：58
- 公司名称：TargetMol Chemicals Inc.
- 联系电话：
- 电子邮件：support@targetmol.com
- 国家：美国
- 产品数：38631
- 优势度：58
- 公司名称：Aladdin Scientific
- 联系电话：+1-+1(833)-552-7181
- 电子邮件：sales@aladdinsci.com
- 国家：美国
- 产品数：57505
- 优势度：58
- 公司名称：MedChemExpress
- 联系电话：--
- 电子邮件：sales@medchemexpress.com
- 国家：美国
- 产品数：6398
- 优势度：58
