描述 宿主 种属反应性 免疫原 偶联性 制备 验证的应用 品牌示例 背景 简介
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兔抗小鼠CTLA-4

描述 宿主 种属反应性 免疫原 偶联性 制备 验证的应用 品牌示例 背景 简介
兔抗小鼠CTLA-4,,结构式
兔抗小鼠CTLA-4
  • CAS号:
  • 英文名:Rabbit Anti-Murine CTLA-4
  • 中文名:兔抗小鼠CTLA-4
  • CBNumber:CB15751476
  • 分子式:
  • 分子量:0
  • MOL File:Mol file

兔抗小鼠CTLA-4性质、用途与生产工艺

  • 描述 兔单克隆抗体[EPR21972-205] to CTLA4
  • 宿主

    Rabbit

  • 种属反应性

    与反应: Mouse

  • 免疫原

    Recombinant fragment within Mouse CTLA4 aa 1-200. The exact sequence is proprietary.

  • 偶联性

    Unconjugated

  • 制备

    This antibody was obtained from a rabbit immunized with purified, recombinant Mouse CTLA-4 / CD152 (rM CTLA-4 / CD152; Catalog#50503-M08H; NP_033973.2; Met1-Phe162).

  • 验证的应用 适用于: Flow Cyt
  • 品牌示例

    Flow Cytometry - Anti-CTLA4 antibody [EPR21972-205] (ab224295)

    兔抗小鼠CTLA-4

    Flow cytometric analysis of mouse primary splenocytes treated with ConA (2.5 μg/ml, 3 days) labeling CTLA4 with ab224295 at 1/100 dilution (Right panel) compared with a Rabbit IgG, monoclonal [EPR25A] - Isotype Control (ab172730) (Left panel). Goat anti rabbit IgG (Alexa Fluor® 488, ab150077) at 1/2000 dilution was used as the secondary antibody.

    A low level of CTLA4 is expected to be on the cell surface; the majority is intracellular, localized to secretory lysosomes (PMID: 11046036). Gated on viable cells.

  • 背景 Cytotoxic T-lymphocyte protein 4, also known as CTLA4 and CD152, is a single-pass type I membrane protein and a member of the immunoglobulin superfamily. It is the second member of the CD28 receptor family. The ligands or counterreceptors for these two proteins are the B7 family members, CD8 (B7-1) and CD86 (B7-2). CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may play an important role in their functions. CD152 or cytotoxic T lymphocyte antigen-4 (CTLA-4) is an essential receptor involved in the negative regulation of T cell activation. Because of its profound inhibitory role, CD152 has been considered a sound susceptible candidate in autoimmunity and a persuasive target for cancer immunotherapy. In particular, recent evidence suggests that CD152 is also important in the homeostasis and function of a population of suppressive cells, termed regulatory T cells (Treg).
  • 简介

    兔抗小鼠CTLA-4是以CTLA-4为抗原的兔多克隆抗体，可以特异性结合CTLA-4。兔抗小鼠CTLA-4主要用于ICC/IF,Dotblot,ELISA,IHC-P,IHC-Fr,Immunomicroscopy,WB等CTLA-4检测实验。

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