MW-150

简介生物活性靶点体外研究体内研究 MW-150 试剂级价格

MW-150

CAS号:1628502-91-9
英文名:MW-150
中文名:MW-150
CBNumber:CB14668247
分子式:C24H23N5
分子量:381.47
MOL File:1628502-91-9.mol

MW-150化学性质

沸点 :606.1±55.0 °C(Predicted)
密度 :1.202±0.06 g/cm3(Predicted)
储存条件 :Store at -20°C
溶解度 :DMSO : 40 mg/mL (104.86 mM; Need ultrasonic)
形态 :A solid
酸度系数(pKa) :7.16±0.42(Predicted)
颜色 :Off-white to light yellow

MW-150性质、用途与生产工艺

简介 MW-150 (MW01-18-150SRM) 是一种选择性，口服有效的，可透过神经系统的 p38α MAPK 抑制剂，Ki 值为 101 nM。MW-150 抑制内源性 p38α MAPK 在活化的神经胶质中磷酸化内源性底物 MK2 的能力。
生物活性 MW-150 (MW01-18-150SRM) 是一种选择性，口服有效的，可透过神经系统的 p38α MAPK 抑制剂，Ki 值为 101 nM。MW-150 抑制内源性 p38α MAPK 在活化的神经胶质中磷酸化内源性底物 MK2 的能力。
靶点

p38α

101 nM (Ki)
体外研究

MW-150 inhibits in a concentration-dependent manner the ability of the endogenous p38α MAPK to phosphorylate an endogenous substrate MK2 in activated glia.
MW-150 blocks in a concentration-dependent manner the increased IL-1β production by activated glia. The IC ₅₀ values are 332 nM and 936 nM for MK2 and IL-1β, respectively.

体内研究

MW-150 (2.5 mg/kg; oral daily for 3-4 months) improves the APP/PS1 transgenic (Tg) mice performance in radial arm water maze (RAWM) and contextual fear conditioning tests.
MW-150 (2.5 mg/kg; given i.p.; daily for 14 days) treatment in APP ^NLh/NLh × PS ^P264L/P264L knock-in mouse (with no overexpression of the amyloid precursor protein) exhibits RAWM behavior indistinguishable from WT mice.

Animal Model:	APP/PS1 transgenic (Tg) mouse (overexpresses amyloid-beta)
Dosage:	2.5 mg/kg
Administration:	Oral daily; 3-4 months (until cognitive impairment is present)
Result:	Improved the Tg mice performance in radial arm water maze (RAWM) and contextual fear conditioning tests.