2-氨基-2-去甲菠烷羧酸
- CAS号:20448-79-7
- 英文名:2-AMINO-2-NORBORNANECARBOXYLIC ACID
- 中文名:2-氨基-2-去甲菠烷羧酸
- CBNumber:CB1384309
- 分子式:C8H13NO2
- 分子量:155.19
- MOL File:20448-79-7.mol
- 熔点 :>300 °C(lit.)
- 沸点 :295.5±23.0 °C(Predicted)
- 密度 :1.256±0.06 g/cm3(Predicted)
- 储存条件 :Keep in dark place,Sealed in dry,Room Temperature
- 溶解度 :Aqueous Acid (Slightly)
- 形态 :Solid
- 酸度系数(pKa) :2.58±0.20(Predicted)
- 颜色 :White
- 水溶解性 :Soluble to 100 mM in water
- CAS 数据库 :20448-79-7(CAS DataBase Reference)
- WGK Germany :3
2-氨基-2-去甲菠烷羧酸性质、用途与生产工艺
- 生物活性 BCH (2-Aminobicyclo-(2,2,1)-heptane-2-carboxylic acid, LAT1-IN-1) 是一种选择性的、竞争性的 system L amino acid transporter 1 (LAT1)的抑制剂。BCH (LAT1-IN-1) 可在癌细胞中诱导凋亡。
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靶点
Target Value LAT1
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体外研究
LAT1-IN-1 (1-100 mM; 3 days; KYSE30 and KYSE150 esophageal cancer cells) treatment suppresses cell proliferation in a dose-dependent manner.
LAT1-IN-1 (30 mM; 24 and 48 hours; KYSE30 and KYSE150 cells) treatment significantly increases cell population in the G0/G1 phase in both KYSE30 and KYSE150 cells, indicating that LAT1-IN-1 induces cell cycle arrest at G1 phase.
LAT1-IN-1 (30 mM; 0-24 hours; KYSE30 and KYSE150 cells) treatment decreases phosphorylation of 4E-BP1 and p70S6K at 30 minutes and the decrease is continued for 24 hours. The amount of mTOR, 4E-BP1, and p70S6K proteins is slightly decreased.Cell Proliferation Assay
Cell Line: KYSE30 and KYSE150 esophageal cancer cells Concentration: 1 mM, 3 mM, 5 mM, 10 mM, 20 mM, 30 mM, 40 mM, 50 mM, or 100 mM Incubation Time: 3 days Result: Cell proliferation was suppressed in a dose-dependent manner. Cell Cycle Analysis
Cell Line: KYSE30 and KYSE150 cells Concentration: 30 mM Incubation Time: 24 and 48 hours Result: Cell cycle arrest. Western Blot Analysis
Cell Line: KYSE30 and KYSE150 cells Concentration: 30 mM Incubation Time: 0 hour, 0.5 hour, 1 hour, 3 hours, 6 hours, 24 hours Result: Phosphorylation of 4E-BP1 and p70S6K was decreased. The amount of mTOR, 4E-BP1, and p70S6K proteins was slightly decreased. -
体内研究
LAT1-IN-1 (200 mg/kg; intravenous injection; daily; for 14 days; male BALB/c nude mice) treatment significantly delays tumor growth and decreases glucose metabolism, indicating that LAT1 inhibition potentially suppresses esophageal cancer growth in vivo.
Animal Model: Male BALB/c nude mice (5-week-old) with KYSE150 cells Dosage: 200 mg/kg Administration: Intravenous injection; daily; for 14 days Result: Significantly delayed tumor growth and decreased glucose metabolism. - 用途 氨基酸跨膜转运的抑制剂。
- 更新日期：2024/11/08
- 产品编号：HY-108540
- 产品名称：2-氨基-2-去甲菠烷羧酸 LAT1-IN-1
- CAS编号：20448-79-7
- 包装：50mg
- 价格：600元
- 更新日期：2024/11/08
- 产品编号：HY-108540
- 产品名称：2-氨基-2-去甲菠烷羧酸 LAT1-IN-1
- CAS编号：20448-79-7
- 包装：10mM * 1mLin Water
- 价格：660元
- 公司名称：SIGMA
- 联系电话：--
- 电子邮件：
- 国家：瑞士
- 产品数：6896
- 优势度：91
