L-NIL

L-NIL化学性质

沸点 :335.2±52.0 °C(Predicted)
密度 :1.22±0.1 g/cm3(Predicted)
储存条件 :-15°C
溶解度 :Water: 50 mg/mL (267.04 mM); DMSO: < 1 mg/mL (insoluble or slightly soluble)
形态 :Solid
酸度系数(pKa) :2.52±0.24(Predicted)
颜色 :White to off-white

L-NIL性质、用途与生产工艺

生物活性 L-NIL 是诱导型一氧化氮合成酶 (iNOS) 的抑制剂，其对 miNOS 的 IC50 值为3.3 μM。
靶点

IC50: 3.3 μM (mouse inducible NO synthase), 92 μM (rat brain constitutive NO synthase)
体外研究

L-NIL produces a concentration-dependent inhibition of both the mouse inducible NOS (miNOS) and the rat brain constitutive NOS (rcNOS) and is considerably more potent for miNOS. The IC ₅₀ values for L-NIL with miNOS and rcNOS are 3.3 and 92 pM, respectively, indicating that L-NIL is 28-fold more selective for miNOS. In addition, L-NIL has approximately 6-fold greater potency for miNOS than either L-NMA or L-NNA.

体内研究

L-NIL (10 and 30 mg/kg, IP) prevents the inflammation, oxidative stress and autophagy induced by renal IR in mice.

Animal Model:	Adult male Balb/c (20-25 g).
Dosage:	10 and 30 mg/kg.
Administration:	Intraperitoneally at the end of CLP and at 6 h after sepsis induction.
Result:	Led to a negligible increase in plasma NGAL compared to sham mice. Led to a significant decrease in both TLR4 and IL1βprotein contents and clusterin transcript. Showed an increase in NFAT5 mRNA levels, as compared with mice treated with vehicle. Promoted a decrease in AR protein expression, as compared with animals treated with vehicle.

L-NIL上下游产品信息

上游原料

下游产品

L-NIL生产厂家