944547-46-0
- CAS号:944547-46-0
- 英文名:Mycro3
- 中文名:944547-46-0
- CBNumber:CB13067564
- 分子式:C24H17ClF2N6O4
- 分子量:526.88
- MOL File:944547-46-0.mol
- 密度 :1.53±0.1 g/cm3(Predicted)
- 储存条件 :Sealed in dry,Store in freezer, under -20°C
- 溶解度 :DMSO : ≥ 100 mg/mL (189.80 mM)
- 酸度系数(pKa) :6.95±0.46(Predicted)
- 形态 :Solid
- 颜色 :Light yellow to yellow
944547-46-0性质、用途与生产工艺
- 生物活性 Mycro 3 是一种有效的选择 Myc-Max 二聚化抑制剂。Mycro 3 可用于胰腺癌的研究。
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靶点
Myc-MAX dimerization
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体外研究
Mycro 3 is a potent and selective c-Myc inhibitor in whole cell assays, with weak inhibitory activity against Activator protein 1 (AP-1). Mycro 3 has a superior specificity profile to its predecessors. Mycro 3 inhibits the interaction between c-Myc and Max. Mycro 3 has high selectivity and inhibits c-Myc/Max dimerization and conjugation with DNA. Mycro 3 exhibits an excellent specificity with IC 50 s of 0.25 and 9.0 µM for cells with intact Myc alleles and Myc-null cells, respectively.
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体内研究
Mycro 3 (100 mg/kg; oral administration; daily for two months) induces marked shrinkage of pancreatic ductal adenocarcinoma (PDA), increases cancer cell apoptosis, and reduces cell proliferation. Tumor growth is also drastically attenuated in Mycro 3-treated NOD/SCID mice carrying orthotopic or heterotopic xenografts of human pancreatic cancer cells.
Animal Model: Moribund Pdx1-cre/KRAS * mice bearing pancreatic ductal adenocarcinoma (PDA) Dosage: 100 mg/kg Administration: Oral administration; daily for two months Result: Increased survival time.
Mycro 3 administration was discontinued after two months, the mouse survived for an additional month.
- 更新日期：2024/11/11
- 产品编号：XW94454746002
- 产品名称：试剂Mycro-3 Mycro-3
- CAS编号：
- 包装：10mg
- 价格：352元
- 更新日期：2024/11/08
- 产品编号：HY-100669
- 产品名称：944547-46-0 Mycro 3
- CAS编号：944547-46-0
- 包装：2mg
- 价格：1200元
- 公司名称：Novachemistry
- 联系电话：44-20819178-90 02081917890
- 电子邮件：info@novachemistry.com
- 国家：英国
- 产品数：4381
- 优势度：58
