SCR7吡嗪
- CAS号:14892-97-8
- 英文名:"6,7-diphenyl-2-sulfanylidene-1H-pteridin-4-one
- 中文名:SCR7吡嗪
- CBNumber:CB12741690
- 分子式:C18H12N4OS
- 分子量:332.38
- MOL File:14892-97-8.mol
- 熔点 :209 °C
- 密度 :1.42±0.1 g/cm3(Predicted)
- 储存条件 :room temp
- 溶解度 :DMSO (Slightly), Methanol (Slightly)
- 酸度系数(pKa) :4.14±0.60(Predicted)
- 形态 :powder
- 颜色 :faintly yellow to dark yellow
- CAS 数据库 :14892-97-8
- 海关编码 :2933.59.8000
SCR7吡嗪性质、用途与生产工艺
- 生物活性 SCR7 pyrazine 是一种 DNA 连接酶 IV (DNA ligase IV) 抑制剂，它以连接酶 IV 依赖的方式阻断非同源末端连接 (NHEJ)。SCR7 pyrazine 也是一种 CRISPR/Cas9 的增强子，可提高 Cas9 介导的同源性定向修复 (HDR) 的效率。SCR7 pyrazine 诱导细胞凋亡 (apoptosis) 并具有抗癌活性。
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靶点
DNA Ligase IV
CRISPR/Cas9 -
体外研究
SCR7 pyrazine (20-100 μM; 24 hours; MCF7 cells) treatment interferes with NHEJ in cells, leading to accumulation of unrepaired double-strand breaks (DSBs).
SCR7 pyrazine treatment shows a dose-dependent decrease in cell proliferation with IC 50 values of 40 μM, 34 μM, 44 μM, 8.5 μM, 120 μM, 10 μM and 50 μM for MCF7, A549, HeLa, T47D, A2780, HT1080 and Nalm6 cells, respectively.
In MCF7 cells, SCR7 pyrazine (20, 40 μM) treatment increases phosphorylation of ATM and activates p53, decreases MDM2, BCL2, resulting in activation of proapoptotic proteins, PUMA and BAX. And the shorter fragments of MCL1, PARP1, Caspase 3, and Caspase 9 cleavage are upregulated in a dose-dependent manner.Western Blot Analysis
Cell Line: MCF7 cells Concentration: 20 μM, 40 μM, 100 μM Incubation Time: 24 hours Result: Showed an increase in levels of gH2AX foci and protein. -
体内研究
SCR7 pyrazine (10 mg/kg; intraperitoneal injection; six doses; BALB/c mice) treatment significantly reduces breast adenocarcinoma-induced tumor and increases lifespan.
Animal Model: BALB/c mice injected with breast adenocarcinoma cells Dosage: 10 mg/kg Administration: Intraperitoneal injection; on alternate days (0, 2, 4, 6, 8, and 10) Result: Significantly reduced breast adenocarcinoma-induced tumor and increased lifespan.
- 更新日期：2024/11/08
- 产品编号：HY-107845
- 产品名称：SCR7 pyrazine
- CAS编号：
- 包装：1 mg
- 价格：386元
- 更新日期：2024/11/08
- 产品编号：HY-107845
- 产品名称：SCR7吡嗪 SCR7 pyrazine
- CAS编号：14892-97-8
- 包装：5mg
- 价格：850元
- 公司名称：TCI AMERICA
- 联系电话：800-4238616
- 电子邮件：sales@tciamerica.com
- 国家：美洲
- 产品数：23653
- 优势度：75
