ChemicalBook CAS数据库列表 新霉胺
新霉胺
- CAS号:3947-65-7
- 英文名:(1'R,3'S,3S,5R,6R)-5-AMINO-2-AMINOMETHYL-6-(4,6-DIAMINO-2,3-DIHYDROXY-CYCLOHEXYLOXY)-TETRAHYDRO-PYRAN-3,4-DIOL
- 中文名:新霉胺
- CBNumber:CB1262623
- 分子式:C12H26N4O6
- 分子量:322.36
- MOL File:3947-65-7.mol
新霉胺化学性质
- 熔点 :225.5°C (rough estimate)
- 比旋光度 :D25+112.8° (c = 1)
- 沸点 :460.98°C (rough estimate)
- 密度 :1.1885 (rough estimate)
- 折射率 :1.6120 (estimate)
- 储存条件 :Hygroscopic, Refrigerator, Under inert atmosphere
- 溶解度 :Aqueous Acid (Slightly), Methanol (Slightly, Heated), Water (Slightly)
- 酸度系数(pKa) :13.24±0.70(Predicted)
- 颜色 :White to Pale Yellow
- 稳定性 :Hygroscopic
新霉胺性质、用途与生产工艺
-
用途
新霉胺是新霉素的降解产物，是一种广谱氨基糖苷类抗生素。
- 生物活性 Neamine 是一种 Neomycin 的无毒衍生物，也是一种广谱氨基糖苷类抗生素。Neamine 是靶向血管生成素 (angiogenin) 的抗血管生成剂。Neamine 具有有效的抗菌，抗肿瘤和神经保护活性。
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体外研究
Neamine (0.625-25 μM; 48 hours; AsPC-1 cells) treatment inhibits ANG-mediated AsPC-1 cell proliferation in a dose-dependent manner in the range of 0.625-25 μM.
Neamine (100 μM) also blocks the nuclear translocation of ANG effectively.Cell Proliferation Assay
Cell Line: AsPC-1 cells Concentration: 0.625 µM, 1.25 µM, 2.5 µM, 5 µM, 10 µM, 25 µM Incubation Time: 48 hours Result: Inhibited angiogenin (ANG)-induced AsPC-1 cells proliferation. -
体内研究
Neamine (30-60 mg/kg; subcutaneous injection; daily; for 14 days; male Balb/c nude mice) has anti-tumor effects on AsPC-1 xenograft models. Neamine reduces the expression levels of ANG, Ki-67 and CD31 in tumor xenografts.
Animal Model: Male Balb/c nude mice (4 weeks old) injected with AsPC-1 cells Dosage: 30 mg/kg, 60 mg/kg Administration: Subcutaneous injection; daily; for 14 days Result: Had anti-tumor effects on AsPC-1 xenograft models.
新霉胺上下游产品信息
上游原料
下游产品
新霉胺生产厂家
- 公司名称：Carbosynth
- 联系电话：--
- 电子邮件：sales@carbosynth.com
- 国家：英国
- 产品数：6005
- 优势度：58
- 公司名称：Leancare Ltd.
- 联系电话：--
- 电子邮件：enquiry@leancare.co.uk
- 国家：英国
- 产品数：6446
- 优势度：42
- 公司名称：Fluorochem Ltd
- 联系电话：--
- 电子邮件：vernam@fluorochem.co.uk
- 国家：英国
- 产品数：6375
- 优势度：65
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