2-[4-[(2,5-二氟苯基)甲氧基]苯氧基]-5-乙氧基苯胺

2-[4-[(2,5-二氟苯基)甲氧基]苯氧基]-5-乙氧基苯胺化学性质

沸点 :485.0±45.0 °C(Predicted)
密度 :1.254±0.06 g/cm3(Predicted)
储存条件 :Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
溶解度 :insoluble in H2O; ≥18.57 mg/mL in DMSO; ≥46.4 mg/mL in EtOH with ultrasonic
形态 :solid
酸度系数(pKa) :4.04±0.10(Predicted)
颜色 :White to khaki

2-[4-[(2,5-二氟苯基)甲氧基]苯氧基]-5-乙氧基苯胺性质、用途与生产工艺

生物活性 SEA0400 是一种选择性的 Na+-Ca2+ exchanger (NCX) 的强效抑制剂，可抑制神经细胞、星形胶质细胞和小胶质细胞中Na+依赖性的Ca2+吸收，对应的IC50值分别为33 nM、5.0 nM和8.3 nM。SEA0400 可防止硝普钠 (SNP) 提高 ERK 和 p38 MAPK 的磷酸化和通过细胞外Ca2+依赖的方式增强reactive oxygen species (ROS) 的产生。
靶点
Target Value
p38 MAPK
()
ERK
()
ROS
()
NCX
(in cultured astrocytes) 5.0 nM
NCX
(in cultured microglia) 8.3 nM
体外研究

SEA0400 inhibits Na ⁺ -dependent ⁴⁵ Ca ²⁺ uptake in cultured neurons, astrocytes, and microglia. IC ₅₀ values of SEA0400 are 33 nM (neurons), 5.0 nM (astrocytes), and 8.3 nM (microglia). SEA0400 prevents sodium nitroprusside (SNP) to increase ERK and p38 MAPK phosphorylation, and production of reactive oxygen species (ROS) in an extracellular Ca ²⁺ -dependent manner.
体内研究

SEA0400 (3 mg/kg + 3 mg/kg/h for 2 h, i.v.) attenuates the infarct volume in the cerebral cortex and striatum, does not affect the mean the regional cortical blood flow in anesthetized rats. SEA0400 protects against the dopaminergic neurotoxicity (determined by dopamine levels in the midbrain and striatum, tyrosine hydroxylase immunoreactivity in the substantia nigra and striatum, striatal dopamine release, and motor deficits) in MPTP-treated C57BL/6J mice.

2-[4-[(2,5-二氟苯基)甲氧基]苯氧基]-5-乙氧基苯胺上下游产品信息

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2-[4-[(2,5-二氟苯基)甲氧基]苯氧基]-5-乙氧基苯胺生产厂家

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