ChemicalBook CAS数据库列表 5'-Fluoro-1H,1'H-[2,3']biindolylidene-3,2'dione3-oxime
5'-Fluoro-1H,1'H-[2,3']biindolylidene-3,2'dione3-oxime
![5'-Fluoro-1H,1'H-[2,3']biindolylidene-3,2'dione3-oxime,861214-33-7,结构式](https://www.chemicalbook.com/CAS/GIF/861214-33-7.gif)
- CAS号:861214-33-7
- 英文名:5'-Fluoro-1H,1'H-[2,3']biindolylidene-3,2'dione3-oxime
- 中文名:5'-Fluoro-1H,1'H-[2,3']biindolylidene-3,2'dione3-oxime
- CBNumber:CB12518955
- 分子式:C16H10FN3O2
- 分子量:295.27
- MOL File:861214-33-7.mol
5'-Fluoro-1H,1'H-[2,3']biindolylidene-3,2'dione3-oxime化学性质
- 沸点 :528.3±50.0 °C(Predicted)
- 密度 :1.57±0.1 g/cm3(Predicted)
- 储存条件 :Keep in dark place,Sealed in dry,Store in freezer, under -20°C
- 溶解度 :DMSO : 83.33 mg/mL (282.22 mM; Need ultrasonic)
- 形态 :Powder
- 酸度系数(pKa) :8.48±0.20(Predicted)
- 颜色 :Light brown to black
5'-Fluoro-1H,1'H-[2,3']biindolylidene-3,2'dione3-oxime性质、用途与生产工艺
- 生物活性 5'-Fluoroindirubinoxime (compound 13) 是Indirubin (HY-N0117) 的衍生物，是FLT3 的抑制剂，其IC50 值为15 nM。
-
靶点
15 nM (FLT3).
-
体外研究
5'-Fluoroindirubinoxime (5’-FIO, compound 13) exhibits IC 50 values of 1.53 μM and 1.27 μM for VEGFR2 and Aurora A, respectively.
5'-Fluoroindirubinoxime (5’-FIO) exhibits IC 50 values of 12.2 μM, 2.1 μM, 3.4 μM and 5.1 μM in A549, SNU-638, HT-1080 and RK3E-ras cancer cells, respectively. 5'-Fluoroindirubinoxime (5’-FIO) induces the apoptosis in RK3E-ras cells. -
体内研究
5'-Fluoroindirubinoxime (5’-FIO, 10 μmol/L/100 μL (~2.95 mg/mL) every other day beginning on day 6, S.C..) exhibits significant anti-tumor activity in rats.
Animal Model: Rat tumor model based RK3E-ras cells. Dosage: S.C.. Administration: 10 μmol/L/100 μL (~2.95 mg/mL) every other day beginning on day 6. Result: Effectively inhibited tumor growth.
5'-Fluoro-1H,1'H-[2,3']biindolylidene-3,2'dione3-oxime上下游产品信息
上游原料
下游产品
5'-Fluoro-1H,1'H-[2,3']biindolylidene-3,2'dione3-oxime 试剂级价格
- 更新日期：2024/11/08
- 产品编号：HY-103464
- 产品名称：5'-Fluoroindirubinoxime
- CAS编号：
- 包装：5 mg
- 价格：1600元
- 更新日期：2024/11/08
- 产品编号：HY-103464
- 产品名称：5'-Fluoro-1H,1'H-[2,3']biindolylidene-3,2'dione3-oxime 5'-Fluoroindirubinoxime
- CAS编号：861214-33-7
- 包装：10mM * 1mLin DMSO
- 价格：1760元
5'-Fluoro-1H,1'H-[2,3']biindolylidene-3,2'dione3-oxime生产厂家
- 公司名称：TOCRIS-US
- 联系电话：--
- 电子邮件：customerservice@tocris.co.uk
- 国家：英国
- 产品数：5726
- 优势度：77
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