ChemicalBook CAS数据库列表 (Z)-1-[2-CHLORO-2-(2,4-DICHLOROPHENYL)ETHENYL]-1H-1,2,4-TRIAZOLE HYDROCHLORIDE
(Z)-1-[2-CHLORO-2-(2,4-DICHLOROPHENYL)ETHENYL]-1H-1,2,4-TRIAZOLE HYDROCHLORIDE
- CAS号:2227372-56-5
- 英文名:(Z)-1-[2-CHLORO-2-(2,4-DICHLOROPHENYL)ETHENYL]-1H-1,2,4-TRIAZOLE HYDROCHLORIDE
- 中文名:(Z)-1-[2-CHLORO-2-(2,4-DICHLOROPHENYL)ETHENYL]-1H-1,2,4-TRIAZOLE HYDROCHLORIDE
- CBNumber:CB1227095
- 分子式:C10H7Cl4N3
- 分子量:310.99
- MOL File:Mol file
(Z)-1-[2-CHLORO-2-(2,4-DICHLOROPHENYL)ETHENYL]-1H-1,2,4-TRIAZOLE HYDROCHLORIDE化学性质
- 溶解度 :Soluble to 5 mM in DMSO with gentle warming and to 5 mM in ethanol with gentle warming
(Z)-1-[2-CHLORO-2-(2,4-DICHLOROPHENYL)ETHENYL]-1H-1,2,4-TRIAZOLE HYDROCHLORIDE性质、用途与生产工艺
- 生物活性 Loreclezole hydrochloride 是一种抗癫痫化合物,是选择性的 GABAA 受体 的调节剂,是β2 或β3亚单位包含受体的正向变构调节剂。
-
靶点
GABA A receptor.
-
体内研究
Loreclezole (10, 25, 50 or 75 mg/kg, i.p. 60 min before measurement of seizure threshold ) results in a dosedependent rise in seizure threshold as measured by the dose of pentylenetetrazolrequired to produce a convulsion 60 min later. Loreclezole also has the least effect on loss of muscle tone as measured by the “pull-up” test.
Animal Model: Adult male Lister Hooded rats. Dosage: 10, 25, 50 or 75 mg/kg. Administration: IP, 60 min before measurement of seizure threshold. Result: Resulted in a dosedependent rise in seizure threshold as measured by the dose of pentylenetetrazolrequired to produce a convulsion 60 min later.
(Z)-1-[2-CHLORO-2-(2,4-DICHLOROPHENYL)ETHENYL]-1H-1,2,4-TRIAZOLE HYDROCHLORIDE上下游产品信息
上游原料
下游产品
(Z)-1-[2-CHLORO-2-(2,4-DICHLOROPHENYL)ETHENYL]-1H-1,2,4-TRIAZOLE HYDROCHLORIDE 试剂级价格
- 更新日期:2024/04/30
- 产品编号:HY-105272A
- 产品名称:Loreclezole hydrochloride
- CAS编号:
- 包装:10 mg
- 价格:5789元
(Z)-1-[2-CHLORO-2-(2,4-DICHLOROPHENYL)ETHENYL]-1H-1,2,4-TRIAZOLE HYDROCHLORIDE生产厂家
- 公司名称:Service Chemical Inc.
- 联系电话:--
- 电子邮件:sales@chemos-group.com
- 国家:德国
- 产品数:6373
- 优势度:71