ChemicalBook CAS数据库列表 2-(1-(4-氯苄基)-1H-吲哚-3-基)-2-氧代-N-(吡啶-4-基)乙酰胺
2-(1-(4-氯苄基)-1H-吲哚-3-基)-2-氧代-N-(吡啶-4-基)乙酰胺
- CAS号:204205-90-3
- 英文名:Indibulin
- 中文名:2-(1-(4-氯苄基)-1H-吲哚-3-基)-2-氧代-N-(吡啶-4-基)乙酰胺
- CBNumber:CB12128730
- 分子式:C22H16ClN3O2
- 分子量:389.83
- MOL File:204205-90-3.mol
2-(1-(4-氯苄基)-1H-吲哚-3-基)-2-氧代-N-(吡啶-4-基)乙酰胺化学性质
- 密度 :1.31±0.1 g/cm3(Predicted)
- 储存条件 :Sealed in dry,Store in freezer, under -20°C
- 溶解度 :DMSO:33.25(Max Conc. mg/mL);85.29(Max Conc. mM)
- 形态 :A solid
- 酸度系数(pKa) :9.38±0.70(Predicted)
- 颜色 :Off-white to yellow
2-(1-(4-氯苄基)-1H-吲哚-3-基)-2-氧代-N-(吡啶-4-基)乙酰胺性质、用途与生产工艺
- 生物活性 Indibulin (ZIO 301, D 24851, Zybulin) 是一种口服的 tubulin assembly 抑制剂，并具有有效的抗癌活性。Indibulin 可诱导有丝分裂的停滞和凋亡。
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靶点
Target Value Tubulin
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体外研究
Indibulin (300-2100 nM; 48 hours) inhibits the proliferation of MCF-7 cells with an IC50 of 150 nM.
Indibulin (300, 600 nM; 48 hours) blockes the cells in the G2/M phase indicating that indibulin blockes the progression of the cell cycle at mitosis.
Indibulin (150-600 nM; 24 hours) induces apoptosis in MCF-7 cells.
Indibulin (150-600 nM; 48 hours) with 300 and 600 nM generates cleaved fragments of PARP protein the treatment of MCF-7 cells.
Cell Proliferation Assay
Cell Line: MCF-7 cells Concentration: 300, 600, 900, 1200, 1500, 1800, 2100 nM Incubation Time: 48 hours Result: Inhibited the proliferation of MCF-7 cells with an IC 50 of 150 nM. Cell Cycle Analysis
Cell Line: MCF-7 cells Concentration: 300, 600 nM Incubation Time: 48 hours Result: Blocked the cells in the G2/M phase of the cell cycle. Apoptosis Analysis
Cell Line: MCF-7 cells Concentration: 150, 300 and 600 nM Incubation Time: 24 hours Result: Induced apoptosis in MCF-7 cells. Western Blot Analysis
Cell Line: MCF-7 cells Concentration: 150, 300 and 600 nM Incubation Time: 48 hours Result: Generated cleaved fragments of PARP protein in 300 and 600 nM.
2-(1-(4-氯苄基)-1H-吲哚-3-基)-2-氧代-N-(吡啶-4-基)乙酰胺上下游产品信息
上游原料
下游产品
2-(1-(4-氯苄基)-1H-吲哚-3-基)-2-氧代-N-(吡啶-4-基)乙酰胺 试剂级价格
- 更新日期：2024/11/08
- 产品编号：HY-13649
- 产品名称：2-(1-(4-氯苄基)-1H-吲哚-3-基)-2-氧代-N-(吡啶-4-基)乙酰胺 Indibulin
- CAS编号：204205-90-3
- 包装：5mg
- 价格：700元
- 更新日期：2024/11/08
- 产品编号：HY-13649
- 产品名称：2-(1-(4-氯苄基)-1H-吲哚-3-基)-2-氧代-N-(吡啶-4-基)乙酰胺 Indibulin
- CAS编号：204205-90-3
- 包装：10mM * 1mLin DMSO
- 价格：770元
2-(1-(4-氯苄基)-1H-吲哚-3-基)-2-氧代-N-(吡啶-4-基)乙酰胺生产厂家
- 公司名称：Ambinter
- 联系电话：--
- 电子邮件：contact@ambinter.com
- 国家：法国
- 产品数：1648
- 优势度：60
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