喹夫拉朋钠
- CAS号:147030-01-1
- 英文名:sodium 3-[1-[(4-chlorophenyl)methyl]-5-(quinolin-2-ylmethoxy)-3-tert-butylsulfanyl-indol-2-yl]-2,2-dimethyl-propanoate
- 中文名:喹夫拉朋钠
- CBNumber:CB11568667
- 分子式:C34H34ClN2NaO3S
- 分子量:0
- MOL File:147030-01-1.mol
- 溶解度 :DMSO : 50 mg/mL (82.08 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
- 形态 :Powder
- 颜色 :White to off-white
喹夫拉朋钠性质、用途与生产工艺
- 生物活性 Quiflapon sodium (MK-591 sodium) 是选择性的,特异性的 FLAP 抑制剂。Quiflapon sodium 是一种有效的,具有口服活性的白三烯生物合成 (leukotriene biosynthesis) 抑制剂。诱导细胞凋亡 (apoptosis)。
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体外研究
Quiflapon sodium (MK591) and SB203580 are able to block SEB-induced human PBMC cell proliferation. Quiflapon sodium (MK591) down regulates three genes [for cathepsin L, IL-17 and guanylate binding protein (GBP)-2] that are up regulated by SEB. Quiflapon sodium (MK591) undergoes apoptosis within hours of treatment. Quiflapon sodium also induces rapid activation of the stress kinase, c-Jun N-terminal kinase (JNK), which plays an important role in the apoptosis process. Quiflapon sodium triggers apoptosis in prostate cancer cells without inhibition of PI3K-Akt, or ERK. Moreover, Quiflapon sodium and LY294002 exert synergistic effect in inducing apoptosis in prostate cancer cells. Quiflapon sodium (MK591) influences cAMP response element-binding protein but not Sp1.
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体内研究
Hyperoxia groups of mice treated with Quiflapon sodium (MK591) (20, 40 mg/kg) show alveolarization that resembles that of room air controls while untreated hyperoxia groups show definite evidence of aberrant alveolarization but no inflammation. Comparison of the Aβ-immunopositive areas between the placebo and Quiflapon sodium (MK591) (320 mg/kg)-treated group reveals a statistically significant reduction of the amyloid burden in the treated mice. Quiflapon sodium also has a significant reduction in brain levels of IL-1β. Mice treated with Quiflapon sodium show a statistically significant decrease in the steady-state levels of total CREB and its phosphorylated form at Ser133.
- 更新日期:2024/11/08
- 产品编号:HY-50714
- 产品名称:Quiflapon sodium
- CAS编号:
- 包装:1 mg
- 价格:465元
- 更新日期:2024/11/08
- 产品编号:HY-50714
- 产品名称:喹夫拉朋钠 Quiflapon sodium
- CAS编号:147030-01-1
- 包装:5mg
- 价格:950元
- 公司名称:TORONTO
- 联系电话:--
- 电子邮件:info@trc-canada.com
- 国家:加拿大
- 产品数:6038
- 优势度:71