L(+)-2-氨基-4-膦酰基丁酸
- CAS号:23052-81-5
- 英文名:L-AP4
- 中文名:L(+)-2-氨基-4-膦酰基丁酸
- CBNumber:CB1141944
- 分子式:C4H10NO5P
- 分子量:183.1
- MOL File:23052-81-5.mol
- 熔点 :207-215 °C
- 沸点 :491.7±55.0 °C(Predicted)
- 密度 :1.628±0.06 g/cm3(Predicted)
- 储存条件 :0-6°C
- 溶解度 :H2O : 50 mg/mL (273.07 mM; Need ultrasonic)
- 酸度系数(pKa) :2.19±0.10(Predicted)
- 形态 :solid
- 颜色 :White
- 水溶解性 :Soluble to 5 mM in water and to 100 mM in 1eq. NaOH
- 敏感性 :Light Sensitive
- CAS 数据库 :23052-81-5(CAS DataBase Reference)
L(+)-2-氨基-4-膦酰基丁酸性质、用途与生产工艺
- 生物活性 L-APB 是一种有效的、代谢型谷氨酸受体 (mGluR) 的特异性激动剂，其对 mGlu4, mGlu8, mGlu6 和 mGlu7 受体的 EC50 值分别为 0.13, 0.29, 1.0, 249 μM。
-
靶点
mGlu 4
0.13 μM (EC 50 )
mGlu8
0.29 μM (EC 50 )
mGlu 6
1.0 μM (EC 50 )
mGlu7
249 μM (EC 50 )
-
体内研究
Paw withdrawal threshold in response to application of von Frey filaments before spinal nerve ligation is 22.6±2.4 g. The mechanical threshold decreases significantly (2.3±0.5 g, P<0.05) within 10 days after nerve ligation and remains stable for at least 8 weeks. Intrathecal injection of 5 to 30 μg of L-APB significantly increases the paw withdrawal threshold in response to application of von Frey filaments in eight nerve-ligated rats in a dose-dependent manner. The maximal effect of L-APB appears within 45 min and gradually subsided in 120 min following intrathecal administration.
- 更新日期：2024/11/08
- 产品编号：HY-100781A
- 产品名称：L(+)-2-氨基-4-膦酰基丁酸 L-AP4
- CAS编号：23052-81-5
- 包装：5mg
- 价格：2950元
- 更新日期：2024/11/08
- 产品编号：HY-100781A
- 产品名称：L-AP4
- CAS编号：
- 包装：10 mM * 1 mLin Water
- 价格：3245元
- 公司名称：Acros Organics
- 联系电话：--
- 电子邮件：info@acros.com
- 国家：比利时
- 产品数：6772
- 优势度：81
