bimoclomol
- CAS号:130493-03-7
- 英文名:bimoclomol
- 中文名:bimoclomol
- CBNumber:CB11336585
- 分子式:C14H20ClN3O2
- 分子量:297.78
- MOL File:130493-03-7.mol
- 储存条件 :Store at -20°C
- 溶解度 :Soluble in DMSO
- 形态 :Oil
- 颜色 :Light yellow to brown
bimoclomol性质、用途与生产工艺
- 生物活性 Bimoclomol 是一种 heat shock protein (HSP) 辅诱导剂,可用于心血管疾病的研究。
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靶点
HSP
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体外研究
Bimoclomol (40 μM) significantly increases coronary flow (CF) in the period of normoxic perfusion (before ischemia). Bimoclomol significantly increases LVDP and CO, but it decreases LVEDP under ischemic conditions. Bimoclomol displays a biphasic effect on the rate of relaxation. Bimoclomol (>10 μM) causes concentration-dependent vasorelaxation, with EC 50 value of 214 μM. Bimoclomol (100 μM) induces vasorelaxation also against 20 mM KCl. However, bimoclomol fails to relax preparations precontracted with serotonin, PGF2 or angiotensin II. Bimoclomol does not affect the stability of Hsp70 or its mRNA. Bimoclomol coinduces Hsp expression via the prolonged activation of the heat shock transcription factor (HSF-1). The effects of bimoclomol are abolished in cells from mice lacking HSF-1. Furthermore, bimoclomol can bind to HSF-1 and induce a prolonged binding of HSF-1 to the respective DNA elements. Bimoclomol (0.1, 1 and 10 μM) improves cell survival of rat neonatal cardiomyocytes compared to vehicle-treated cells. Bimoclomol (0.01 to 10 μM) significantly elevates HSP70 levels, based on the time of exposure. Pretreatment with bimoclomol for 24 h significantly increases survival of cells.
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体内研究
Bimoclomol (1 and 5 mg/kg) decreases the ST-segment elevation induced by coronary occlusion by 56% and 80%, respectively, in anesthetized dogs.
- 更新日期:2024/08/19
- 产品编号:HY-U00398
- 产品名称:Bimoclomol
- CAS编号:
- 包装:1 mg
- 价格:2181元
- 更新日期:2024/08/19
- 产品编号:HY-U00398
- 产品名称:bimoclomol Bimoclomol
- CAS编号:130493-03-7
- 包装:5mg
- 价格:4800元
- 公司名称:北京新研汇医药研发有限公司
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