盐酸特拉唑嗪

Ki: 6.51 nM (α1a-adrenoceptor), 1.01 nM (α1b-adrenoceptor) and 1.97 nM (α1d-adrenoceptor)

(R)-Terazosin is low affinity for α2a, α2B and α2c-adrenoceptor with K _i values of 3.85 μM, 0.33 μM and 0.37 μM, respectively.
(R)-Terazosin may prove to be a useful probe in understanding the functional role of subtypes of adrenoceptors in various tissues. Because it is a weaker antagonist at α2B sites than its enantiomer, it may be possible to use (R)-Terazosin to differentiate between pharmacological effects mediated by subtypes of α2-adrenoceptors in animal studies.

(R)-Terazosin shows antagonism of at rat atrial α2B receptor with a pEC ₃₀ of 5.69. (R)-Terazosin shows antagonism of at rat vas deferens α1A and α2A receptor with pA ₂ values of 7.5 and 5.31, respectively.