安五脂素
- CAS号:107534-93-0
- 英文名:Anwuligan
- 中文名:安五脂素
- CBNumber:CB11229216
- 分子式:C20H24O4
- 分子量:328.4
- MOL File:107534-93-0.mol
- 熔点 :70-71℃
- 沸点 :467.0±40.0 °C(Predicted)
- 密度 :1.159
- 闪点 :236℃
- 储存条件 :Store at -20°C
- 溶解度 :DMSO : ≥ 30 mg/mL (91.35 mM)
- 酸度系数(pKa) :10.19±0.20(Predicted)
- 形态 :powder
- 颜色 :White
- LogP :5.220 (est)
- 海关编码 :29329990
安五脂素性质、用途与生产工艺
- 生物活性 Macelignan ((+)-Anwulignan; Anwuligan) 是一种从肉豆蔻中分离得到的生物活性木脂素 (lignan)。Macelignan 具有多种药理活性，包括抗炎、抗癌、抗糖尿病和神经保护活性。
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靶点
COX-2
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体外研究
Macelignan (1-50 μM; 72 hours) does not reduce cell viability alone, however, UVB treatment, even at the lowest dose of 30 mJ/cm 2 , reduces HaCaT cell viability in a dose-dependent mannner,it reduces approximately 80% of control values at 100 μM in hacat cells.Macelignan (0.1-1 μM; 24 hours) decreases COX-2 expression in a concentration-dependent manner,and at the highest concentration of macelignan (1 μM) , COX-2 expression is inhibited by almost 50% in hacat cells.
Cell Viability Assay
Cell Line: Hacat cells Concentration: 1 μM; 2.5 μM; 5 μM; 10 μM; 15 μM; 50 μM Incubation Time: 72 hours Result: Induced cell death by UVB irradiation at 30 mJ/cm 2 from 10 μM. Western Blot Analysis
Cell Line: Hacat cells Concentration: 0.1 μM; 0.5 μM;1 μM Incubation Time: 24 hours Result: Reduced UVB-induced COX-2 expression in cells. -
体内研究
Macelignan (oral administration; 15 mg/kg; every day for three weeks) exhibits in vivo anti-diabetic effects. The baseline (day 0) fasting blood glucose levels does not differ between groups; at the end of the experiment, the values of the Macelignan-treated group are significantly lower compared to the diabetic control group in C57BL/KsJ- db/db mice.
Animal Model: Male C57BL/KsJ- db/db mice Dosage: 15 mg/kg Administration: Oral administration; 15 mg/kg; every day for three weeks Result: Significantly reduced the blood glucose levels in mice. - 化学性质 白色结晶粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于五味子Schisandra chinensis 的根或皮。
- 用途 安五脂素有抗肿瘤、凝血的作用。
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用途
用于含量测定/鉴定/药理实验等
药理药效:抗肿瘤、凝血
- 更新日期：2024/11/08
- 产品编号：HY-N0064
- 产品名称：Macelignan
- CAS编号：
- 包装：1 mg
- 价格：350元
- 更新日期：2024/11/08
- 产品编号：HY-N0064
- 产品名称：安五脂素 Macelignan
- CAS编号：107534-93-0
- 包装：5mg
- 价格：700元
- 公司名称：Novachemistry
- 联系电话：44-20819178-90 02081917890
- 电子邮件：info@novachemistry.com
- 国家：英国
- 产品数：4381
- 优势度：58
- 公司名称：Carbosynth
- 联系电话：--
- 电子邮件：sales@carbosynth.com
- 国家：英国
- 产品数：6005
- 优势度：58
