安五脂素

生物活性靶点体外研究体内研究安五脂素试剂级价格

安五脂素

CAS号:107534-93-0
英文名:Anwuligan
中文名:安五脂素
CBNumber:CB11229216
分子式:C20H24O4
分子量:328.4
MOL File:107534-93-0.mol

安五脂素化学性质

熔点 :70-71℃
沸点 :467.0±40.0 °C(Predicted)
密度 :1.159
闪点 :236℃
储存条件 :Store at -20°C
溶解度 :DMSO : ≥ 30 mg/mL (91.35 mM)
酸度系数(pKa) :10.19±0.20(Predicted)
形态 :powder
颜色 :White
LogP :5.220 (est)

安全信息

海关编码 :29329990

安五脂素性质、用途与生产工艺

生物活性 Macelignan ((+)-Anwulignan; Anwuligan) 是一种从肉豆蔻中分离得到的生物活性木脂素 (lignan)。Macelignan 具有多种药理活性，包括抗炎、抗癌、抗糖尿病和神经保护活性。
靶点

COX-2

体外研究

Macelignan (1-50 μM; 72 hours) does not reduce cell viability alone, however, UVB treatment, even at the lowest dose of 30 mJ/cm ² , reduces HaCaT cell viability in a dose-dependent mannner,it reduces approximately 80% of control values at 100 μM in hacat cells.Macelignan (0.1-1 μM; 24 hours) decreases COX-2 expression in a concentration-dependent manner,and at the highest concentration of macelignan (1 μM) , COX-2 expression is inhibited by almost 50% in hacat cells.

Cell Viability Assay

Cell Line:	Hacat cells
Concentration:	1 μM; 2.5 μM; 5 μM; 10 μM; 15 μM; 50 μM
Incubation Time:	72 hours
Result:	Induced cell death by UVB irradiation at 30 mJ/cm ² from 10 μM.

Western Blot Analysis

Cell Line:	Hacat cells
Concentration:	0.1 μM; 0.5 μM;1 μM
Incubation Time:	24 hours
Result:	Reduced UVB-induced COX-2 expression in cells.

体内研究

Macelignan (oral administration; 15 mg/kg; every day for three weeks) exhibits in vivo anti-diabetic effects. The baseline (day 0) fasting blood glucose levels does not differ between groups; at the end of the experiment, the values of the Macelignan-treated group are significantly lower compared to the diabetic control group in C57BL/KsJ- db/db mice.

Animal Model:	Male C57BL/KsJ- db/db mice
Dosage:	15 mg/kg
Administration:	Oral administration; 15 mg/kg; every day for three weeks
Result:	Significantly reduced the blood glucose levels in mice.