ChemicalBook CAS数据库列表 溴法罗明
溴法罗明
- CAS号:63638-91-5
- 英文名:Brofaromine
- 中文名:溴法罗明
- CBNumber:CB11178149
- 分子式:C14H16BrNO2
- 分子量:310.19
- MOL File:63638-91-5.mol
溴法罗明化学性质
- 沸点 :404.0±45.0 °C(Predicted)
- 密度 :1.386±0.06 g/cm3(Predicted)
- 储存条件 :Store at -20°C
- 溶解度 :DMSO: 250 mg/mL (805.96 mM)
- 形态 :Solid
- 酸度系数(pKa) :9.99±0.10(Predicted)
- 颜色 :Off-white to light yellow
溴法罗明性质、用途与生产工艺
- 生物活性 Brofaromine (CGP 11305A) 是一种单胺氧化酶 (MAO) 抑制剂,抑制 MAO-A,IC50 为 0.2 μM。
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靶点
IC50: 0.2 μM (MAO-A)
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体外研究
In order to assess whether the protective effect is related to the inhibition of the MAO-A or due to another mechanism, the effect of Brofaromine (CGP 11305A, BRO) is determined on the activity of MAO-A in cultured cortical cells. It shows, firstly, that cultured cortical cells have a significant MAO-A activity, and secondly, that Brofaromine inhibits the enzyme in a concentration-dependent manner. The IC 50 is 0.19 μM for Brofaromine . Hill coefficient is 0.96. The enzyme is almost completely inhibited at 10 μM . Brofaromine inhibits MAO-A activity of our cultured cortical cells in a concentration-dependent manner. The IC 50 range of Brofaromine is 0.01 μM to 0.1 μM.
溴法罗明上下游产品信息
上游原料
下游产品
溴法罗明生产厂家
- 公司名称:TargetMol Chemicals Inc.
- 联系电话:+1-781-999-5354 +1-00000000000
- 电子邮件:marketing@targetmol.com
- 国家:美国
- 产品数:19892
- 优势度:58
- 公司名称:Aladdin Scientific
- 联系电话:+1-+1(833)-552-7181
- 电子邮件:sales@aladdinsci.com
- 国家:美国
- 产品数:52927
- 优势度:58
- 公司名称:MedChemExpress
- 联系电话:--
- 电子邮件:sales@medchemexpress.com
- 国家:美国
- 产品数:6398
- 优势度:58