ChemicalBook CAS数据库列表 人牛吡啶APELIN-13
人牛吡啶APELIN-13
- CAS号:217082-60-5
- 英文名:PYR-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE-OH
- 中文名:人牛吡啶APELIN-13
- CBNumber:CB1113712
- 分子式:C69H108N22O16S
- 分子量:1533.8
- MOL File:217082-60-5.mol
人牛吡啶APELIN-13化学性质
- 密度 :1.51±0.1 g/cm3(Predicted)
- 储存条件 :Keep in dark place,Sealed in dry,Store in freezer, under -20°C
- 形态 :Powder
- 酸度系数(pKa) :3.56±0.10(Predicted)
- 颜色 :White to off-white
- 水溶解性 :Soluble to 1 mg/ml in sterile water
- 序列 :Pyr-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe-OH
人牛吡啶APELIN-13性质、用途与生产工艺
- 生物活性 [Pyr1]-Apelin-13 是一种高效的，选择性的内源性 apelin 受体激动剂。
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体外研究
[Pyr1]-apelin-13 encapsulation in lipoPEG particles (lipoPEG-PA13) results in sustained and extended drug release under physiological conditions.
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体内研究
[Pyr1]-apelin-13 nanocarriers in a mouse model of pressure-overload induced heart failure demonstrate a sustainable long-term effect of [Pyr1]-apelin-13 in preventing cardiac dysfunction. [Pyr1] apelin-13 (1, 5 μg) improves locomotor activity and reduces pain symptoms, cavity size and caspase-3 levels in rats. [Pyr1] apelin-13 (1, 5 μg) significantly increases thermal paw withdrawal latency. [Pyr1] apelin-13 in 5 μg dose also produces significant attenuation in paw withdrawal threshold compared to SCI animals from the second week post SCI.
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参考质量标准
外观:白色粉末
纯度(HPLC) ≥98.0%
醋酸根含量≤12.0%
水分含量≤8.0%
肽含量≥80.0%
内毒素≤50EU/mg
氨基酸组成分析≤±10%
人牛吡啶APELIN-13上下游产品信息
上游原料
下游产品
人牛吡啶APELIN-13 试剂级价格
- 更新日期：2024/11/08
- 产品编号：HY-P1033
- 产品名称：人牛吡啶APELIN-13 [Pyr1]-Apelin-13
- CAS编号：217082-60-5
- 包装：1mg
- 价格：784元
- 更新日期：2024/11/08
- 产品编号：HY-P1033
- 产品名称：[Pyr1]-Apelin-13
- CAS编号：
- 包装：2 mg
- 价格：1254元
人牛吡啶APELIN-13生产厂家
- 公司名称：Carbosynth
- 联系电话：--
- 电子邮件：sales@carbosynth.com
- 国家：英国
- 产品数：6005
- 优势度：58
- 公司名称：TOCRIS-US
- 联系电话：--
- 电子邮件：customerservice@tocris.co.uk
- 国家：英国
- 产品数：5726
- 优势度：77
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