8-羟基-1,3,6-萘三磺酸
- CAS号:3316-02-7
- 英文名:ζ-Stat
- 中文名:8-羟基-1,3,6-萘三磺酸
- CBNumber:CB0860691
- 分子式:C10H8O10S3
- 分子量:384.35952
- MOL File:3316-02-7.mol
- 储存条件 :Store at -20°C
- 形态 :Solid
- 颜色 :Light brown to brown
- 水溶解性 :Water : 62.5 mg/mL (162.61 mM; Need ultrasonic)
- EPA化学物质信息 :1,3,6-Naphthalenetrisulfonic acid, 8-hydroxy- (3316-02-7)
8-羟基-1,3,6-萘三磺酸性质、用途与生产工艺
- 生物活性 ζ-Stat (NSC37044) 是一种特异且非典型的 PKC-ζ 的抑制剂，IC50 值为 5 μM。ζ-Stat 可以减少黑色素瘤细胞系的增殖并诱导细胞凋亡，在体外具有抗肿瘤活性。
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靶点
aPKC-ζ
5 μM (IC 50 )
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体外研究
ζ-Stat (0.1-20 µM) shows only 13% inhibition on PKC-ι at 20 μM, but shows a significant inhibition on PKC-ζ as 51% at 5 μM level.
ζ-Stat (0.1-10 µM; 3 d) significantly decreases cell proliferation of SK-MEL-2 and MeWo upon increasing the concentrations.
ζ-Stat (7 or 10 µM; 24-72 h) and 5-FU in combination is able to decrease the viability of LoVo CRC cells by more than 75%.
ζ-Stat (5 µM; 3 d) shows a significant diminution of phosphorylated, total PKC-ζ, Bcl-2 and PARP levels, and increases Caspase-3 and cleaved-PARP levels in SK-MEL-2 and MeWo cells.
ζ-Stat (5 µM; 1-10 h) does not show significant cytotoxicity on MEL-F-NEO, SK-MEL-2 and MeWo cells.
Cell Proliferation Assay
Cell Line: MEL-F-NEO, SK-MEL-2 and MeWo cells Concentration: 0.1, 0.5, 1, 2.5, 5, 7.5, 10 µM Incubation Time: 3 days Result: Decreased proliferation by 47.7% for 5 µM in SK-MEL-2 cells and by 50.6% for 5 µM in MeWo cells.
Showed significant inhibitions on MEL-F-NEO cells 19.3% (P ≤ 0.05) at 10 μM.Western Blot Analysis
Cell Line: SK-MEL-2 and MeWo cells Concentration: 5 µM Incubation Time: 3 days Result: Decreased phosphorylated and total PKC-ζ levels.
- 更新日期：2024/11/08
- 产品编号：HY-123979
- 产品名称：ζ-Stat
- CAS编号：
- 包装：1 mg
- 价格：1200元
- 更新日期：2024/11/08
- 产品编号：HY-123979
- 产品名称：8-羟基-1,3,6-萘三磺酸 ζ-Stat
- CAS编号：3316-02-7
- 包装：5mg
- 价格：3000元
- 公司名称：TargetMol Chemicals Inc.
- 联系电话：+1-781-999-5354 +1-00000000000
- 电子邮件：marketing@targetmol.com
- 国家：美国
- 产品数：32165
- 优势度：58
- 公司名称：TargetMol Chemicals Inc.
- 联系电话：
- 电子邮件：support@targetmol.com
- 国家：美国
- 产品数：38632
- 优势度：58
- 公司名称：MedChemExpress
- 联系电话：--
- 电子邮件：sales@medchemexpress.com
- 国家：美国
- 产品数：6398
- 优势度：58
