BAY 607550

BAY 607550化学性质

沸点 :680.7±65.0 °C(Predicted)
密度 :1.24±0.1 g/cm3(Predicted)
储存条件 :-20°C
溶解度 :DMSO:21.65(Max Conc. mg/mL);45.43(Max Conc. mM)
Ethanol:10.0(Max Conc. mg/mL);20.98(Max Conc. mM)
酸度系数(pKa) :14.54±0.20(Predicted)
形态 :powder
颜色 :white to light brown

BAY 607550性质、用途与生产工艺

生物活性 Bay 60-7550 是有效，选择性的 PDE2 抑制剂，Ki 值为3.8 nM。
靶点

Ki: 3.8±0.2 nM (PDE2)
体外研究

Bay 60-7550 (1 μM) increases cGMP in the neuronal cultures compared with control [F(6,14)=12.97, p<0.05 for Bay 60-7550]. Bay 60-7550 in the presence of NMDA (30 μM) results in further increases in cGMP compared with NMDA alone. The NMDA receptor antagonist MK-801 (10 μM) blocks both Bay 60-7550+NMDA-induced elevation in cGMP in neuronal cultures. Compared with untreated control cells, proliferation of PASMCs from IPAH patients is significantly reduced by BAY 60-7550 (1 μM).
体内研究

The PDE2 inhibitors Bay 60-7550 (1 mg/kg) reverses restraint stress-induced alterations in behavior, resulting in increased percentages of open-arm entries and open-arm time compared with the vehicle + restraint stress condition. In nonstressed mice, Bay 60-7550 produces a dose-dependent increase in percentages of open-arm entries and open-arm time compared with the vehicle-treated group; significant increases are observed at a dose of 3 mg/kg. In nonstressed mice, Bay 60-7550 increases, in a dose-dependent manner, the number of head-dips and time spent head-dipping, compared with vehicle-treated mice; significant increases are observed at doses of 1 and 3 mg/kg.

BAY 607550上下游产品信息

上游原料

下游产品

BAY 607550 试剂级价格

BAY 607550生产厂家