ANATABINE DICITRATE
- CAS号:
- 英文名:Anatabine dicitrate
- 中文名:ANATABINE DICITRATE
- CBNumber:CB08021508
- 分子式:
- 分子量:0
- MOL File:Mol file
- 形态 :Solid
- 颜色 :White to off-white
ANATABINE DICITRATE性质、用途与生产工艺
- 生物活性 Anatabine dicitrate 是一种烟草生物碱,可以穿过血脑屏障。Anatabine dicitrate 是一种有效的 α4β2 nAChR 激动剂。Anatabine dicitrate 通过阻止淀粉样蛋白前体蛋白的 β 裂解,抑制 NF-κB 激活,并降低淀粉样 β (Aβ) 的产生。Anatabine dicitrate 具有抗炎作用,可用于神经退行性疾病的研究。
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靶点
NF-κB
Amyloid-β (Aβ)
α4β2 nAChR -
体外研究
Anatabine (600 μg/mL; 24 hours; SHSY-5Y cells) treatment shows an inhibition of p65 NF-κB phosphorylation.
Anatabine (500-1000μg/mL; 30 minutes; SHSY-5Y cells) treatment fully prevents the increase in BACE-1 mRNA levels induced by TNF-α. After 24 hours, Anatabine treatment shows a dose-dependent inhibition of BACE-1 protein levels.
Anatabine dose dependently inhibits Aβ 1-40 and Aβ 1-42 with an approximate half maximal inhibitory concentration of 640 μg/mL for both Aβ 1-40 and Aβ 1-42 in 7W CHO cells. Anatabine inhibits sAPPβ secretion without impacting sAPPα suggesting that Anatabine is preventing the β-cleavage of amyloid precursor protein (APP).Western Blot Analysis
Cell Line: SHSY-5Y cells Concentration: 600 μg/mL Incubation Time: 24 hours Result: An inhibition of p65 NF-κB phosphorylation was observed. RT-PCR
Cell Line: SHSY-5Y cells Concentration: 500 μg/mL, 1000 μg/mL Incubation Time: 30 minutes Result: Fully prevented the increase in BACE-1 mRNA levels induced by TNF-α. -
体内研究
Anatabine (0.5-2 mg/kg; intraperitoneal injection; daily; for 4 days; transgenic mouse) treatment significantly lowers brain soluble Aβ 1-40 and Aβ 1-42 levels in a transgenic mouse model of Alzheimer's disease.
Animal Model: Transgenic mice overexpressing the human APP695sw mutation and the presenilin-1 mutation M146L (Tg PS1/APPsw) (50 week-old) Dosage: 0.5 mg/kg, 2 mg/kg Administration: Intraperitoneal injection; daily; for 4 days Result: Significantly lowered brain soluble Aβ 1-40 and Aβ 1-42 levels in a transgenic mouse model of Alzheimer's disease.
- 更新日期:2024/08/19
- 产品编号:HY-19918A
- 产品名称:Anatabine dicitrate
- CAS编号:
- 包装:1 mg
- 价格:1136元
- 更新日期:2024/08/19
- 产品编号:HY-19918A
- 产品名称:ANATABINE DICITRATE Anatabine dicitrate
- CAS编号:
- 包装:5mg
- 价格:2500元
- 公司名称:MedChemExpress
- 联系电话:--
- 电子邮件:sales@medchemexpress.com
- 国家:美国
- 产品数:6398
- 优势度:58