ANATABINE DICITRATE
- CAS号:
- 英文名:Anatabine dicitrate
- 中文名:ANATABINE DICITRATE
- CBNumber:CB08021508
- 分子式:
- 分子量:0
- MOL File:Mol file
- 形态 :Solid
- 颜色 :White to off-white
ANATABINE DICITRATE性质、用途与生产工艺
- 生物活性 Anatabine dicitrate 是一种烟草生物碱，可以穿过血脑屏障。Anatabine dicitrate 是一种有效的 α4β2 nAChR 激动剂。Anatabine dicitrate 通过阻止淀粉样蛋白前体蛋白的 β 裂解，抑制 NF-κB 激活，并降低淀粉样 β (Aβ) 的产生。Anatabine dicitrate 具有抗炎作用，可用于神经退行性疾病的研究。
-
靶点
NF-κB
Amyloid-β (Aβ)
α4β2 nAChR -
体外研究
Anatabine (600 μg/mL; 24 hours; SHSY-5Y cells) treatment shows an inhibition of p65 NF-κB phosphorylation.
Anatabine (500-1000μg/mL; 30 minutes; SHSY-5Y cells) treatment fully prevents the increase in BACE-1 mRNA levels induced by TNF-α. After 24 hours, Anatabine treatment shows a dose-dependent inhibition of BACE-1 protein levels.
Anatabine dose dependently inhibits Aβ 1-40 and Aβ 1-42 with an approximate half maximal inhibitory concentration of 640 μg/mL for both Aβ 1-40 and Aβ 1-42 in 7W CHO cells. Anatabine inhibits sAPPβ secretion without impacting sAPPα suggesting that Anatabine is preventing the β-cleavage of amyloid precursor protein (APP).Western Blot Analysis
Cell Line: SHSY-5Y cells Concentration: 600 μg/mL Incubation Time: 24 hours Result: An inhibition of p65 NF-κB phosphorylation was observed. RT-PCR
Cell Line: SHSY-5Y cells Concentration: 500 μg/mL, 1000 μg/mL Incubation Time: 30 minutes Result: Fully prevented the increase in BACE-1 mRNA levels induced by TNF-α. -
体内研究
Anatabine (0.5-2 mg/kg; intraperitoneal injection; daily; for 4 days; transgenic mouse) treatment significantly lowers brain soluble Aβ 1-40 and Aβ 1-42 levels in a transgenic mouse model of Alzheimer's disease.
Animal Model: Transgenic mice overexpressing the human APP695sw mutation and the presenilin-1 mutation M146L (Tg PS1/APPsw) (50 week-old) Dosage: 0.5 mg/kg, 2 mg/kg Administration: Intraperitoneal injection; daily; for 4 days Result: Significantly lowered brain soluble Aβ 1-40 and Aβ 1-42 levels in a transgenic mouse model of Alzheimer's disease.
- 更新日期：2024/08/19
- 产品编号：HY-19918A
- 产品名称：Anatabine dicitrate
- CAS编号：
- 包装：1 mg
- 价格：1136元
- 更新日期：2024/08/19
- 产品编号：HY-19918A
- 产品名称：ANATABINE DICITRATE Anatabine dicitrate
- CAS编号：
- 包装：5mg
- 价格：2500元
- 公司名称：ChemeGen 中国
- 联系电话： 18818260767
- 电子邮件：sales@chemegen.com
- 国家：中国
- 产品数：11289
- 优势度：58
- 公司名称：成都超九八生物科技有限公司
- 联系电话：13348960310 13348960310
- 电子邮件：3003867561@qq.com
- 国家：中国
- 产品数：10000
- 优势度：58
- 公司名称：天津普西唐生物医药科技有限公司
- 联系电话：010-60605840 15801484223;
- 电子邮件：psaitong@jm-bio.com
- 国家：中国
- 产品数：29778
- 优势度：58
