(+/-)-BLEBBISTATIN
- CAS号:674289-55-5
- 英文名:(+/-)-BLEBBISTATIN
- 中文名:(+/-)-BLEBBISTATIN
- CBNumber:CB0787697
- 分子式:C18H16N2O2
- 分子量:292.33
- MOL File:674289-55-5.mol
- 熔点 :210-212°C
- 沸点 :507.3±60.0 °C(Predicted)
- 密度 :1.31±0.1 g/cm3(Predicted)
- 储存条件 :−20°C
- 溶解度 :Chloroform (Slightly), Dichloromethane, DMSO, Ethyl Acetate, Methanol
- 形态 :Bright yellow solid.
- 酸度系数(pKa) :11.15±0.20(Predicted)
- 颜色 :Yellow
- CAS 数据库 :674289-55-5
- 危险品标志 :Xn
- 危险类别码 :20/21/22-36/37/38
- 安全说明 :26-36/37
(+/-)-BLEBBISTATIN性质、用途与生产工艺
- 生物活性 Blebbistatin 是一种选择性的非肌肉肌球蛋白 II (NMII) 抑制剂，可促进角膜内皮细胞的定向迁移并加速伤口愈合，并更好地保留细胞连接完整性和屏障功能。
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靶点
Non-muscle myosin II (NMII)
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体外研究
The therapeutic potential of targeting NMII to enhance CEC migration is investigated using bovine corneal endothelial cells (BCECs). Blebbistatin, a direct myosin motor inhibitor, promotes migration and directional persistence in CECs through decreasing actin retrograde flow and increasing lamellipodial protrusion persistence to accelerate wound healing in vitro.
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体内研究
Blebbistatin (0.05 mL, 20 μM; intracameral injection; daily; for 6 days; New Zealand white rabbits) treatment promotes wound healing in rabbit corneal endothelial scraping model.
Animal Model: New Zealand white rabbits (16-20 weeks; 3-3.5 kg) Dosage: 0.05 mL; 20 μM Administration: Intracameral injection; daily; for 6 days Result: Resulted in significant improvement of corneal clarity and corneal edema resolution, implying the restoration of an intact corneal endothelial monolayer. -
用途
Blebbistatin blocked myosin II-dependent cell processes. It blocks cell blebbing rapidly and reversibly. Also rapidly disrupted directed cell migration and cytokinesis in vertebrate cell. It blocks both blebbing and cytokinesis at 50-100μM.
- 公司名称：CLEARSYNTH LABS LTD.
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- 国家：印度
- 产品数：6257
- 优势度：58
