ChemicalBook CAS数据库列表 PYRIDOXALPHOSPHATE-6-AZOPHENYL-2';4'-DISULFONIC ACID;
PYRIDOXALPHOSPHATE-6-AZOPHENYL-2';4'-DISULFONIC ACID;
- CAS号:192575-19-2
- 英文名:PPADS TETRASODIUM SALT
- 中文名:PYRIDOXALPHOSPHATE-6-AZOPHENYL-2';4'-DISULFONIC ACID;
- CBNumber:CB0758079
- 分子式:C14H15N3NaO12PS2
- 分子量:535.37
- MOL File:192575-19-2.mol
PYRIDOXALPHOSPHATE-6-AZOPHENYL-2';4'-DISULFONIC ACID;化学性质
- 储存条件 :−20°C
- 溶解度 :H2O: >10 mg/mL
- 形态 :solid
- 颜色 :red to orange
- 水溶解性 :Soluble to 100 mM in water
- 稳定性 :Unstable in Aqueous Solution
安全信息
- 安全说明 :22-24/25
- WGK Germany :3
PYRIDOXALPHOSPHATE-6-AZOPHENYL-2';4'-DISULFONIC ACID;性质、用途与生产工艺
- 生物活性 PPADS tetrasodiuma 是一种非选择性 P2X 受体拮抗剂。PPADS tetrasodiuma 阻断重组P2X1、-2、-3、-5，IC50 范围为1～2.6 μM。PPADS-tetrasodiuma 阻断天然 P2Y2 样 (IC50~0.9 mM) 和重组 P2Y4 (IC50~15 mM) 受体。PPADS tetrasodiuma 是豚鼠气道平滑肌 Na/Ca²⁺ 交换逆模式的抑制剂。
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体外研究
PPADS tetrasodiuma (1-30 μM; 10-50 minutes) inhibits Na+/Ca2+ exchanger reverse mode (NCXREV) in a time- and concentration dependent manner.
PPADS tetrasodiuma is effective at other native and recombinant P2XRs. At human P2XRs sensitivity to PPADS tetrasodiuma depended on the subtype and was highest at the hP2X1, -2, -3, -5, and -7Rs with an IC50 of ∼1–3 and ∼30 μM for the hP2X4R. -
体内研究
PPADS tetrasodiuma (15-60 mg/100g body weight (BW); i.p.; every 12 hours for 8 days) inhibits glomerular mesangial cells (MC) proliferation without altering proliferation of non-MC in vivo in mesangial proliferative glomerulonephritis.
Animal Model: Male Sprague-Dawley ratsweighing 160 to 200 g (anti-Thy1 disease mode) Dosage: 15 mg/100g BW, 30 mg/100g BW, 60 mg/100g BW Administration: i.p.; every 12 hours for 8 days (the first PPADS injection was administered 60 minutes after disease induction, and the loading dose always contained double the amount of PPADS compared to the following injections.) Result: Specifically and dose-dependently reduced early (day 3) glomerular mesangial cell proliferation without altering proliferation of non-MC.
PYRIDOXALPHOSPHATE-6-AZOPHENYL-2';4'-DISULFONIC ACID;上下游产品信息
上游原料
下游产品
PYRIDOXALPHOSPHATE-6-AZOPHENYL-2';4'-DISULFONIC ACID; 试剂级价格
- 更新日期：2024/11/08
- 产品编号：HY-101044
- 产品名称：PYRIDOXALPHOSPHATE-6-AZOPHENYL-2';4'-DISULFONIC ACID; PPADS tetrasodium
- CAS编号：192575-19-2
- 包装：1mg
- 价格：370元
- 更新日期：2024/11/08
- 产品编号：HY-101044
- 产品名称：PYRIDOXALPHOSPHATE-6-AZOPHENYL-2';4'-DISULFONIC ACID; PPADS tetrasodium
- CAS编号：192575-19-2
- 包装：5mg
- 价格：750元
PYRIDOXALPHOSPHATE-6-AZOPHENYL-2';4'-DISULFONIC ACID;生产厂家
- 公司名称：NACALAI
- 联系电话：--
- 电子邮件：info-tech@nacalai.co.jp
- 国家：日本
- 产品数：6046
- 优势度：75
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