TYR-ARG-GLN-SER-MET-ASN-GLN-GLY-SER-ARG-SER-THR-GLY-CYS-ARG-PHE-GLY-THR-CYS-THR-MET-GLN-LYS-LEU-ALA-HIS-GLN-ILE-TYR-GLN-PHE-THR-ASP-LYS-ASP-LYS-ASP-GLY-MET-ALA-PRO-ARG-ASN-LYS-ILE-SER-PRO-GLN-GLY-TYR-NH2 (DISULFIDE BRIDGE:CYS14-CYS19 )
- CAS号:159964-38-2
- 英文名:ADRENOMEDULLIN 1-50, RAT
- 中文名:TYR-ARG-GLN-SER-MET-ASN-GLN-GLY-SER-ARG-SER-THR-GLY-CYS-ARG-PHE-GLY-THR-CYS-THR-MET-GLN-LYS-LEU-ALA-HIS-GLN-ILE-TYR-GLN-PHE-THR-ASP-LYS-ASP-LYS-ASP-GLY-MET-ALA-PRO-ARG-ASN-LYS-ILE-SER-PRO-GLN-GLY-TYR-NH2 (DISULFIDE BRIDGE:CYS14-CYS19 )
- CBNumber:CB0745303
- 分子式:C62H97N21O18S
- 分子量:1456.63
- MOL File:159964-38-2.mol
- 密度 :1.51±0.1 g/cm3(Predicted)
- 储存条件 :-20°C
- 酸度系数(pKa) :3.34±0.10(Predicted)
- 形态 :Solid
- 颜色 :White to off-white
- WGK Germany :3
TYR-ARG-GLN-SER-MET-ASN-GLN-GLY-SER-ARG-SER-THR-GLY-CYS-ARG-PHE-GLY-THR-CYS-THR-MET-GLN-LYS-LEU-ALA-HIS-GLN-ILE-TYR-GLN-PHE-THR-ASP-LYS-ASP-LYS-ASP-GLY-MET-ALA-PRO-ARG-ASN-LYS-ILE-SER-PRO-GLN-GLY-TYR-NH2 (DISULFIDE BRIDGE:CYS14-CYS19 )性质、用途与生产工艺
- 生物活性 Adrenomedullin (1-50), rat 是由 50 个氨基酸组成的多肽,能够通过激活 CGRP1 受体来诱导动脉血管舒张。
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靶点
CGRP1 receptor
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体外研究
Adrenomedullin (1-50), rat is a 50 amino acid peptide, which induces a selective arterial vasodilation via activation of CGRP1 receptor.
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体内研究
Adrenomedullin (1-50), rat causes a dose-dependent and endothelium-independent vasodilation on the arterial mesenteric vasculature, and this effect is inhibited by CGRP1 receptor antagonist. Adrenomedullin (1-50), rat activates CGRP1 receptor in the double-perfused mesenteric bed of the rat. Adrenomedullin (1-50) ameliorates pulmonary vascular structural remodeling of hypoxic rats with incresed plasma NO and H(2)S concentrations. Adrenomedullin (1-50) also regulates the development of hypoxic pulmonary hypertension and hypoxic pulmonary vascular structural remodeling, through promoting NO and H(2)S production in hypoxic rats.
- 更新日期:2024/11/08
- 产品编号:HY-P1534
- 产品名称:TYR-ARG-GLN-SER-MET-ASN-GLN-GLY-SER-ARG-SER-THR-GLY-CYS-ARG-PHE-GLY-THR-CYS-THR-MET-GLN-LYS-LEU-ALA-HIS-GLN-ILE-TYR-GLN-PHE-THR-ASP-LYS-ASP-LYS-ASP-GLY-MET-ALA-PRO-ARG-ASN-LYS-ILE-SER-PRO-GLN-GLY-TYR-NH2 (DISULFIDE BRIDGE:CYS14-CYS19 ) Adrenomedullin (1-50), rat
- CAS编号:159964-38-2
- 包装:500μg
- 价格:2500元
- 更新日期:2024/11/08
- 产品编号:HY-P1534
- 产品名称:TYR-ARG-GLN-SER-MET-ASN-GLN-GLY-SER-ARG-SER-THR-GLY-CYS-ARG-PHE-GLY-THR-CYS-THR-MET-GLN-LYS-LEU-ALA-HIS-GLN-ILE-TYR-GLN-PHE-THR-ASP-LYS-ASP-LYS-ASP-GLY-MET-ALA-PRO-ARG-ASN-LYS-ILE-SER-PRO-GLN-GLY-TYR-NH2 (DISULFIDE BRIDGE:CYS14-CYS19 ) Adrenomedullin (1-50), rat
- CAS编号:159964-38-2
- 包装:1mg
- 价格:3500元
- 公司名称:SIGMA
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- 国家:瑞士
- 产品数:6896
- 优势度:91