3-氨基苯甲酰胺

3-氨基苯甲酰胺化学性质

熔点 :115-116 °C (lit.)
沸点 :250.42°C (rough estimate)
密度 :1.1778 (rough estimate)
折射率 :1.5769 (estimate)
储存条件 :room temp
溶解度 :ethanol: 50 mg/mL, clear, faintly yellow
形态 :powder
酸度系数(pKa) :16.26±0.50(Predicted)
颜色 :white to off-white
水溶解性 :Soluble in dimethylformamide (~30 mg/ml), dimethyl sulfoxide (~30 mg/ml), phosphate buffered saline (pH7.2) (~2 mg/ml), water (25 mg/ml), and ethanol (25 mg/ml).
敏感性 :Light Sensitive
BRN :2802373
稳定性 :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
LogP :-0.330
CAS 数据库 :3544-24-9(CAS DataBase Reference)
NIST化学物质信息 :3-NH2-C6H4CONH2(3544-24-9)

安全信息

3-氨基苯甲酰胺性质、用途与生产工艺

生物活性 3-Aminobenzamide (3-ABA , 3-Amino Benzamide, 3-AB) 是一种有效的Poly(ADP-ribose)polymerase (PARP)抑制剂，还可通过caspase非依赖性的方式来抑制SCI脊髓损伤后的细胞凋亡。
靶点
Target Value
PARP
()
体外研究

3-Aminobenzamide (PARP-IN-1) (>1 μM) causes more than 95% inhibition of PARP activity without significant cellular toxicity. INO-1001 significantly sensitizes CHO cells by blocking most of the DNA repair occurring between radiation fractions. 3-Aminobenzamide significantly improves endothelial function by enhancing the acetylcholine-induced, endothelium-dependent, nitric oxide mediated vasorelaxation after exposure with 400 μM H ₂ O ₂ .
体内研究

In a db/db (Lepr db/db ) mouse model, 3-Aminobenzamide ameliorates diabetes-induced albumin excretion and mesangial expansion, and also decreases diabetes-induced podocyte depletion. 3-Aminobenzamide (1.6 mg/kg via intracerebral injection) prevents NAD ⁺ depletion and improves water maze performance after controlled cortical impact (CCI) in mice.
化学性质白色粉末，熔点115-117℃。
用途有机化工原料中间体。
类别有毒物品
毒性分级中毒
急性毒性口服-野鸟LD50: 1000 毫克/公斤
可燃性危险特性可燃;燃烧产生有毒氮氧化物烟雾
储运特性库房通风低温干燥
灭火剂干粉、泡沫、砂土、二氧化碳, 雾状水

3-氨基苯甲酰胺上下游产品信息

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下游产品

3-氨基苯甲酰胺试剂级价格

3-氨基苯甲酰胺生产厂家

3544-24-9, 3-氨基苯甲酰胺相关搜索:

Target	Value
PARP ()