ChemicalBook CAS数据库列表 CN128
CN128
- CAS号:1335282-05-7
- 英文名:CN128
- 中文名:CN128
- CBNumber:CB06197999
- 分子式:C15H18ClNO3
- 分子量:295.76
- MOL File:1335282-05-7.mol
CN128化学性质
- 储存条件 :Store at -20°C
- 溶解度 :Methanol: 5mg/mL,Methanol:PBS (pH 7.2) (1:1): 0.5mg/mL
- 形态 :Solid
- 颜色 :Off-white to light brown
CN128性质、用途与生产工艺
- 生物活性 CN128 hydrochloride (CN328) 是一种有口服活性、选择性的铁螯合剂 (iron chelator)。CN128 被用于 β-地中海贫血的研究。
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体外研究
CN128 hydrochloride possesses a high selectivity for iron(III) over others metals.
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体内研究
CN128 hydrochloride (450 μmol/kg; p.o.) exhibits a good iron scavenging efficacy in rat.
The iron removal efficacies of CN128 displays a dose-dependent behavior.
CN128 hydrochloride lacks genetic toxicity.
CN128 hydrochloride (75 μmol/kg; i.g.) possesses good oral bioavailability (82.6%), high maximal plasma concentration, and low clearance rats after an oral dose of 75 μmol/kg.
CN128 hydrochloride is well-tolerated, with no mortality being observed at the higher dose levels in rats.
Animal Model: Male SD rats (300 g) Dosage: 450 μmol/kg Administration: Oral gavage, 1 hour after 59 Fe-ferritin injection Result: Exhibited good iron scavenging activity. Animal Model: Sprague-Dawley rats (200~250 g) Dosage: 75 μmol/kg (Pharmacokinetic Analysis) Administration: Oral administration Result: AUC values= 16.38 mg/L•h, C max =8.671 mg/L.
CN128上下游产品信息
上游原料
下游产品
CN128 试剂级价格
- 更新日期:2024/11/08
- 产品编号:HY-131060
- 产品名称:CN128 hydrochloride
- CAS编号:
- 包装:1 mg
- 价格:909元
- 更新日期:2024/11/08
- 产品编号:HY-131060
- 产品名称:CN128 CN128 hydrochloride
- CAS编号:1335282-05-7
- 包装:5mg
- 价格:2000元
CN128生产厂家
- 公司名称:MedChemExpress
- 联系电话:--
- 电子邮件:sales@medchemexpress.com
- 国家:美国
- 产品数:6398
- 优势度:58