LANREOTIDE ACETATE

LANREOTIDE ACETATE化学性质

LANREOTIDE ACETATE性质、用途与生产工艺

生物活性 Lanreotide (Laromustine, Angiopeptin, BIM 23014, Dermopeptin, Ipstyl, ITM-014, Somatulina, Somatuline, Lanreotidum) acetate 是一种天然生长抑素肽的类似物，是生长激素 growth hormone (GH)的生理抑制剂。Lanreotide 也具有抗肿瘤作用。
体外研究

Lanreotide acetate (BIM 23014 acetate) (24-48 hours; 100 nM; GH3 cells) combines with radiation increasing in apoptotic sub-G1 proportion.
Lanreotide acetate results in a dose-dependent decrease in GH3 cell colony forming units. Lanreotide acetate at doses of 1, 10, 100, and 1000 nM results in cell survival rates of 75, 56, 39 and 27% respectively. The IC50 (50% inhibition of cell growth) was 57 nM.
Lanreotide acetate inhibits GH-secreting pituitary adenoma cell proliferation and hormone release in vitro.

体内研究

Lanreotide acetate (2.5-10mg/kg; s.c.; daily for 5 days) resluts in tumor growth inhibition.

Animal Model:	Male nude mice, 8 weeks old and 20–25 g in body weight (GH3 tumor-bearing nude mice)
Dosage:	2.5, 5, 10 mg/kg
Administration:	Subcutaneous; daily for 5 days
Result:	Produced tumor growth inhibition.

LANREOTIDE ACETATE上下游产品信息

上游原料

下游产品

LANREOTIDE ACETATE 试剂级价格

LANREOTIDE ACETATE生产厂家