Histatin 5 (TFA)
- CAS号:
- 英文名:Histatin 5 (TFA)
- 中文名:Histatin 5 (TFA)
- CBNumber:CB05848757
- 分子式:
- 分子量:0
- MOL File:Mol file
- 形态 :Solid
- 颜色 :White to off-white
Histatin 5 (TFA)性质、用途与生产工艺
- 生物活性 Histatin 5 TFA 抑制宿主基质金属蛋白酶 MMP-2 和 MMP-9 活性,IC50s 分别为 0.57 和 0.25 μM。
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靶点
IC 50 : 0.57 μM (MMP-2), 0.25 μM (MMP-9)
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体外研究
Histatin 5 is a member of a family of low-molecular-weight salivary proteins secreted by parotid, submandibular, and sublingual glands. Using biotinylated gelatin as a substrate, Histatin 5 is found to inhibit the activity of the host matrix metalloproteinases MMP-2 and MMP-9 with IC 50s of 0.57 and 0.25 μM, respectively. To localize the domain responsible for this inhibition, three peptides containing different regions of Histatin 5 are synthesized and tested as inhibitors of MMP-9. Peptides comprising residues 1 to 14 and residues 4 to 15 of Histatin 5 show much lower inhibitory activities (IC 50s , 21.4 and 20.5 μM, respectively), while a peptide comprising residues 9 to 22 showed identical activity to Histatin 5 against MMP-9. Kinetic analysis of the inhibition of the Arg-gingipain reveals that Histatin 5 is a competitive inhibitor, affecting only the Km with a Ki of 15 μM . Histatin 5 is an inhibitor of mitochondrial respiration.The human salivary antifungal peptide Histatin 5 is taken up by Candida albicans cells and associates intracellularly with mitochondria. Histatin 5 inhibits respiration of isolated C. albicans mitochondria as well as the respiration of intact blastoconidia in a dose and time-dependent manner. Histatin 5 at a concentration of 33 uM inhibits state 2 respiration.
- 更新日期:2024/04/30
- 产品编号:HY-P0273A
- 产品名称:Histatin 5 (TFA) Histatin 5 TFA
- CAS编号:
- 包装:500μg
- 价格:1200元
- 更新日期:2024/04/30
- 产品编号:HY-P0273A
- 产品名称:Histatin 5 (TFA) Histatin 5 TFA
- CAS编号:
- 包装:1mg
- 价格:1800元
- 公司名称:MedChemExpress
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- 国家:美国
- 产品数:6398
- 优势度:58