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ANTI-NF-KB P65抗体

描述 宿主 应用 种属反应性 制备方法 品牌示例 背景 靶点背景 下游应用
ANTI-NF-KB P65抗体,,结构式
ANTI-NF-KB P65抗体
  • CAS号:
  • 英文名:Anti-NF-kB p65 Antibody
  • 中文名:ANTI-NF-KB P65抗体
  • CBNumber:CB05716674
  • 分子式:
  • 分子量:0
  • MOL File:Mol file

ANTI-NF-KB P65抗体性质、用途与生产工艺

  • 描述

    Anti-NF-kB p65 Antibody, Mouse Monoclonal

  • 宿主

    Mouse

  • 应用

    ELISA,FCM,ICC/IF

  • 种属反应性

    Human

  • 制备方法 This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human RELA / Transcription factor p65 (rh RELA / Transcription factor p65; Catalog#12054-H09E; Q04206-1; Met 1-Tyr 306). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
  • 品牌示例

    Anti-NF-kB p65 Antibody, Mouse Monoclonal---Cat: 12054-MM04
    Anti-NF-kB p65 Antibody
    Immunofluorescence staining of human RELA (NF-KB p65) in Hela cells. Cells were fixed with 4% PFA, permeabilzed with 1% Triton X-100 in PBS, blocked with 10% serum, and incubated with Mouse anti-human RELA monoclonal antibody (1:100) at 4℃ overnight. Then cells were stained with the Alexa Fluor® 488-conjugated Goat Anti-mouse IgG secondary antibody (green) and counterstained with DAPI (blue). Positive staining was localized to cytoplasm.

  • 背景 RELA (v-rel reticuloendotheliosis viral oncogene homolog A), also known as Nuclear factor NF-kappa-B p65 subunit, or Transcription factor p65, is a transcription factor expressed in growth plate chondrocytes where it facilitates chondrogenesis. The v-rel avian reticuloendotheliosis viral oncogene homolog A (RELA) gene encodes the major component of the NF-?B complex. NF-kappaB is a generic name for an evolutionarily conserved transcription-factor system that contributes to the mounting of an effective immune response but is also involved in the regulation of cell proliferation, development, and apoptosis. The implication of NF-kappaB in central biological processes and its extraordinary connectivity to other signaling pathways raise a need for highly controlled regulation of NF-kappaB activity at several levels. The mammalian Rel/NF-kappaB family of transcription factors, including RelA, c-Rel, RelB, NF-kappaB1 (p5 and its precursor p15), and NF-kappaB2 (p52 and its precursor p1), plays a central role in the immune system by regulating several processes ranging from the development and survival of lymphocytes and lymphoid organs to the control of immune responses and malignant transformation.
  • 靶点背景 NF-κB（核因子激活的B细胞的κ-轻链增强）是一种蛋白质复合物，其控制转录的DNA，细胞因子产生和细胞存活。NF-κB几乎存在于所有动物细胞类型中，并参与细胞对刺激的反应，如应激，细胞因子，自由基，重金属，紫外线照射，氧化LDL和细菌或病毒抗原。NF-κB在调节对感染的免疫应答中起关键作用。NF-κB的不正确调节与癌症，炎症和自身免疫疾病，感染性休克，病毒感染和免疫发育不当有关。NF-κB也与突触可塑性和记忆过程有关。
  • 下游应用 ANTI-NF-KB P65抗体是一类可以特异性结合ANTI-NF-KB P65的克隆抗体，主要用于检测ANTI-NF-KB P65的Western Blot、IHC-P、IF、ELISA、Co-IP等多种免疫学实验。
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