描述 宿主 种属反应性 偶联物 制备 验证的应用 品牌示例 背景 简介
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ANTI-MMP9抗体

描述 宿主 种属反应性 偶联物 制备 验证的应用 品牌示例 背景 简介
ANTI-MMP9抗体,,结构式
ANTI-MMP9抗体
  • CAS号:
  • 英文名:Anti-MMP9 antibody
  • 中文名:ANTI-MMP9抗体
  • CBNumber:CB05716159
  • 分子式:
  • 分子量:0
  • MOL File:Mol file

ANTI-MMP9抗体性质、用途与生产工艺

  • 描述 明胶酶B抗体LS-B2486是一种针对大鼠明胶酶B (MMP9)的未偶联兔多克隆抗体。对人、小鼠和大鼠均有反应。IHC, IP和WB验证。
  • 宿主 Rabbit
  • 种属反应性 Rat, Human, Mouse
  • 偶联物 Unconjugated
  • 制备 Produced in rabbits immunized with purified, recombinant Human MMP9/MMP-9/CLG4B (rh MMP9/MMP-9/CLG4B; Catalog#10327-H08H; NP_004985.2; Met1-Asp707). MMP9/MMP-9/CLG4B specific IgG was purified by Human MMP9/MMP-9/CLG4B affinity chromatography.
  • 验证的应用

    IHC
    IHC - Paraffin (5 µg/ml)
    IHC - Frozen (1:50)
    Western blot (1:1000)
    Immunoprecipitation (1:250)

  • 品牌示例

    LSBio
    IHCPlus™ Polyclonal Rabbit anti‑Rat MMP9 / Gelatinase B Antibody (IHC, WB) LS‑B2486

    ANTI-MMP9抗体

  • 背景 Matrix metalloproteinases (MMPs) are neutral proteinases that are involved in the breakdown and remodeling of the extracellular matrix (ECM) under a variety of physiological and pathological conditions, such as morphogenesis, differentiation, angiogenesis and tissue remodeling, as well as pathological processes including inflammation, arthritis, cardiovascular diseases, pulmonary diseases and tumor invasion. MMP9, also known as 92-kDa gelatinase B/type IV collagenase, is secreted from neutrophils, macrophages, and a number of transformed cells, and is the most complex family member in terms of domain structure and regulation of its activity. It plays an important role in tissue remodelling in normal and pathological inflammatory processes. MMP-9 is a major secretion product of macrophages and a component of cytoplasmic granules of neutrophils, and is particularly important in the pathogenesis of inflammatory, infectious, and neoplastic diseases in many organs including the lung. This enzyme is also secreted by lymphocytes and stromal cells upon stimulation by inflammatory cytokines, or upon delivery of bi-directional activation signals following integrin-mediated cell-cell or cell-extracellular matrix (ECM) contacts. Since the integrity of the tissue architecture is closely dependent of the delicate balance between MMPs and their inhibitors, excessive production of MMP-9 is linked to tissue damage and degenerative inflammatory disorders. As a consequence, regulation of gene transcription and tissue-specific expression of MMP-9 in normal and diseased states are being actively investigated to pave the way for new therapeutic targets. In addition, the dramatic overexpression of MMP-9 in cancer and various inflammatory conditions clearly points to the molecular mechanisms controlling its expression as a potential target for eventual rational therapeutic intervention.
  • 简介 ANTI-MMP9抗体是以ANTI-MMP9为抗原制得的免疫抗体，可以特异性结合ANTI-MMP9。主要用于检测ANTI-MMP9的Western Blot、IHC-P、IF、ELISA、Co-IP等多种免疫学实验。
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