ChemicalBook CAS数据库列表 4-[[4-Amino-5-cyano-6-[(1,1-dimethylethyl)amino]-2-pyridinyl]amino]benzamide
4-[[4-Amino-5-cyano-6-[(1,1-dimethylethyl)amino]-2-pyridinyl]amino]benzamide
生物活性 靶点 体外研究 体内研究
4-[[4-Amino-5-cyano-6-[(1,1-dimethylethyl)amino]-2-pyridinyl]amino]benzamide 试剂级价格
![4-[[4-Amino-5-cyano-6-[(1,1-dimethylethyl)amino]-2-pyridinyl]amino]benzamide,1206170-62-8,结构式](https://www.chemicalbook.com/CAS/20200119/GIF/1206170-62-8.gif)
- CAS号:1206170-62-8
- 英文名:4-[[4-Amino-5-cyano-6-[(1,1-dimethylethyl)amino]-2-pyridinyl]amino]benzamide
- 中文名:4-[[4-Amino-5-cyano-6-[(1,1-dimethylethyl)amino]-2-pyridinyl]amino]benzamide
- CBNumber:CB04902737
- 分子式:C17H20N6O
- 分子量:324.38
- MOL File:1206170-62-8.mol
4-[[4-Amino-5-cyano-6-[(1,1-dimethylethyl)amino]-2-pyridinyl]amino]benzamide化学性质
- 沸点 :601.0±55.0 °C(Predicted)
- 密度 :1.28±0.1 g/cm3(Predicted)
- 储存条件 :Store at -20°C
- 溶解度 :<32.44mg/ml in DMSO; <6.49mg/ml in ethanol
- 酸度系数(pKa) :16.23±0.50(Predicted)
- 形态 :Solid
- 颜色 :White to off-white
4-[[4-Amino-5-cyano-6-[(1,1-dimethylethyl)amino]-2-pyridinyl]amino]benzamide性质、用途与生产工艺
- 生物活性 TC-Mps1-12 是一种高效、选择性的 Mps1 抑制剂，其 IC50 值为 6.4 nM。
-
靶点
IC50: 6.4 nM (Mps1)
-
体外研究
TC-Mps1-12 inhibits the growth of pMps1 cell lines with IC50 values of 131 nM in autophosphorylation assay.
TC-Mps1-12 (72 hours) inhibits the growth of cells in a dose-dependent manner and with an IC 50 values of 0.84 μM.
Cell Viability Assay
Cell Line: 549 cells Concentration: Incubation Time: 72 hours Result: Inhibited the growth of cells in a dose-dependent manner and with an IC 50 values of 0.84 μM. -
体内研究
TC-Mps1-12 (25-100 mg/kg; p.o.; daily; for 19 days) inhibits the growth of A549 cells in a dose-dependent manner in vivo. At a dose of 100 mg/kg, TC-Mps1-12 exhibits 47% tumor growth inhibition without body weight loss.
TC-Mps1-12 shows good PK properties with a Cmax of 3542 ng/mL and AUC of 6604 ng h/mL at an oral dose of 25 mg/kg.
Animal Model: A549 mouse xenograft model Dosage: 25 mg/kg, 50 mg/kg, 100 mg/kg Administration: Oral administration; once daily; for 19 days Result: Inhibited the growth of A549 cells in a dose-dependent manner. Animal Model: A549 mouse xenograft model (pharmacokinetic ) Dosage: 25 mg/kg Administration: Oral administration Result: C max = 3542 ng/mL, AUC = 6604 ng h/mL
4-[[4-Amino-5-cyano-6-[(1,1-dimethylethyl)amino]-2-pyridinyl]amino]benzamide上下游产品信息
上游原料
下游产品
4-[[4-Amino-5-cyano-6-[(1,1-dimethylethyl)amino]-2-pyridinyl]amino]benzamide 试剂级价格
- 更新日期：2025/02/08
- 产品编号：HY-110115
- 产品名称：4-[[4-Amino-5-cyano-6-[(1,1-dimethylethyl)amino]-2-pyridinyl]amino]benzamide TC-Mps1-12
- CAS编号：1206170-62-8
- 包装：1mg
- 价格：1750元
- 更新日期：2025/02/08
- 产品编号：HY-110115
- 产品名称：4-[[4-Amino-5-cyano-6-[(1,1-dimethylethyl)amino]-2-pyridinyl]amino]benzamide TC-Mps1-12
- CAS编号：1206170-62-8
- 包装：5mg
- 价格：5200元
4-[[4-Amino-5-cyano-6-[(1,1-dimethylethyl)amino]-2-pyridinyl]amino]benzamide生产厂家
- 公司名称：TOCRIS-US
- 联系电话：--
- 电子邮件：customerservice@tocris.co.uk
- 国家：英国
- 产品数：5726
- 优势度：77
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